FORMULATION AND EVALUATION OF LIQUISOLID COMPACTS OF RISPERIDONE

According to the liquisolid methodology, liquid medications in solutions or suspension form of water insoluble drugs in suitable nonvolatile liquid solvent can be converted into readily flowing and adequately compressible powders by a simple addition with certain powder substrates, referred to as the carrier and coating materials. Release rates are enhanced due to the increased wetting properties and surface area of drug available for dissolution. Liquisolid tablets of Risperidone containing MCC and Aerosil 200 as powder substrates of different excipient ratios from 5 to 35 were prepared using PG as non volatile solvent. Before compression, powdered mass were evaluated for flow properties such as bulk density, tapped density, angle of repose, Carr’s compressibility index and Hausner’s ratio and the formulated liquisolid tablets were evaluated for post compression parameters such as weight variation, hardness, friability, drug content uniformity, and disintegration time. The release rates of all products were assessed using the USP type II dissolution apparatus. It was observed that maximum drug dissolution rates exhibited by systems that have powder substrates with optimum carrier to coating ratios (20:1). FTIR spectra and DSC illustrated no significant interaction between drug and excipients used. From this study it was concluded that the liquisolid technique is a promising alternative for improvement of dissolution property of water-insoluble drugs.