Journal article Open Access
Jyoti Negi*, Tulsi Bisht, Popin Kumar
The application of nanotechnology in pharmaceutical industries has received great attention from last decade. A lot of research work is going on in this field due to its safety, efficacy and better patient compliance. Different production methods have been developed for nanoparticles and most of the methods use two basic steps; emulsification and size reduction to Nano size. Homogenization techniques are most frequently employed using hot and cold homogenization or ultra-sonication for the production. Few methods based on emulsification are also applied used earlier for polymeric nanoparticle production. Hot high pressure homogenization and ultra-sonication are most commonly used method with scale up workability but costly equipment is biggest drawback. Other methods used to produce lipid nanoparticles are possible in a laboratory setup with no expensive equipments are needed but scale up is still a problem with such method along with regulatory problems associated with high surfactants concentrations in these formulations. This review focus on different methods used for lipid nanoparticles production with their procedure, advantages and disadvantages associated with them.