Journal article Open Access

FORMULATION DEVELOPMENT AND EVALUATION OF SUBLINGUAL FILM OF RESPERIDONE.

Tekade B. W., Jadhao U. T., Patil V.R., Koli B.D., Minal Pachpande.

The aim of formulation of fast dissolving sublingual film of Risperidone was to provide quicker onset of action in short duration of time and in addition to provide immediate action after administration of dosage form. Pre-formulation study was carried out by FTIR with pure drug (Risperidone) and formulation mixture (Risperidone-HPMC K4M and Risperidone-Pectin). It was observed that disintegration time varies from 19 to 30 sec for all the formulations. Weight variation varies from 49.33 mg to 66.66 mg. All the formulations were evaluated for folding endurance, surface pH, Tensile Strength, thickness and weight variation. It was also observed that HPMC K4M & Pectin was able to modulate the Risperidone release as lower amount of HPMC K4M as well as Pectin resulted in release of drug a faster rate.

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