ETHANOLIC VESICLES: A NOVEL APPROACH TO ENHANCE TRANSDERMAL DRUG DELIVERY

Transdermal drug delivery is the approach in which the drug is embedded into the reservoir within the patch and it pass through the skin into the blood stream. The various techniques has developed to disrupts the skin barrier and deliver drug into the body through the intact skin. Liposomes in the Transdermal drug delivery system limits their use at clinical and industrial level due to its unstable nature. Ethosomes have the ability to reach into the deep into skin. It contains the ethanol in high concentration . ethosomes act by the ethanol effect and ethosomes effect. Ethosomes are flexible and also pass through the narrow constrictions. This article covers the basic information regarding the advantages of ethosomes, mechanism of penetration , method of preparation, evaluation parameter, it also covers the information like formulation aspect of ethosomes, challenges and opportunities and marketed formulation. The applicability of ethosomes in various fields like cosmetics, analgesics, anesthetics, corticosteroids, anticancer agents, insulin.