A RANDOMIZED TRIAL TO REPORT THE EFFECTIVENESS OF FERROUS SULFATE (FS) ALONG WITH IRON POLYMALTOSE COMPLEX (IPC) FOR ANEMIA MANAGEMENT

Objective: The purpose of the research was to find out the effectiveness of FS (Ferrous Sulfate) with IPC (Iron Polymaltose Complex) in managing anemia of iron deficiency in nonage.

Material and Methods: The design of the research was a randomized trial research which was held at Services Hospital, Lahore from February to November 2017. The numbers of iron deficiency anaemia children included in the research are seventy having to age between six months to six years. Researcher irregularly distributed them into two categories and give iron polymaltose complex along with ferrous sulfate category, IPC and FS for the time period of two months respectively. The dosage of iron arrangement given was 6mg/kg/day of preliminary iron in three separate doses. The researcher followed up the research participator’s after two-month duration and recorded the effectiveness of FS and IPC in term of regulation of haemoglobin along with serum ferritin.

Results: Among seventy enrolled children, the number of male and female children were thirty-nine (55.7%) and thirty-one (44.3%) respectively. the average age of enrolled children is 2.46 years ± 1.36 standard deviation. Sixty percent of the children having age less than two years. The average weight of selected children was (10.7 kilogram). The number of children having a weight less than twelve kilograms was forty-six (65.7%), twenty-four (34.3%) were twelve kilograms or more than this. Average Hb and ferritin prior to the start of treatment in selected research children were 7.85 g/dl ± 0.82 standard deviation and 8.22 ng/ml ± 2.42 standard deviation respectively. Average post-treatment Hb and ferritin in selected research children were 10.9 g/dl ± 0.90 g/dl ± 0.82 standard deviations and 42.8 ng/ml ± 21 SD respectively. Docility was batter in (94.3%) children of iron polymaltose complex category and (85.7%) children in the ferrous sulfate category. Researcher during comparison of both the categories noticed effectiveness in thirty-two (91.4%) children of iron polymaltose complex category and thirty (85.8%) children in ferrous sulfate category that was unimportant statistically with P value = 0.45. The effectiveness of iron polymaltose complex with respect to ferrous sulfate was statistically unimportant in entire age categories i.e. age category of six months to less than two years (P-value = 0.71), age category of children of two to six years (P-value = 0.45) and in males and females (P value = 0.13) & (P-value = 0.50) respectively. Researcher did not notice any statistical expressive variation in the effectiveness between iron polymaltose complex as well as ferrous sulfate category in children weighing less than twelve kilograms (P-value = 0.48), children greater than or equal to twelve kilograms (P-value = 0.8), children with batter docility (P value =0.42) and children with poor docility (P value =0.61).  

Conclusion: Finding of the research declared that there was statistically unimportant variation in the effectiveness rate of IPC and FS when utilized as informal iron substitute management in IDA children. FS and IPC could be utilized as substitute drugs as both have balanced effectiveness.

Keywords: Iron deficiency anaemia (IDA), ferrous sulfate (FS), iron polymaltose complex (IPC)