Published October 13, 2016
| Version v1
Journal article
Open
Pulmonary arterial hypertension: Basic knowledge for clinicians.
Creators
- 1. Departamento de Cirurgia e Fisiologia da Faculdade de Medicina da Universidade do Porto
- 2. Departamento de Cirurgia e Fisiologia da Faculdade de Medicina da Universidade do Porto; Unidade de Investigação Cardiovascular
Description
Pulmonary arterial hypertension is a progressive syndrome based on diverse aetiologies, which is characterized by a persistent increase in pulmonary vascular resistance and overload of the right ventricle, leading to heart failure and death. Currently, none of the available treatments is able to cure pulmonary arterial hypertension; additional research is therefore needed to unravel the associated pathophysiological mechanisms. This review summarizes current knowledge related to this disorder, and the several experimental animal models that can mimic pulmonary arterial hypertension and are available for translational research.
Notes
This work was funded by the project DOCnet (NORTE-01-0145-FEDER-000003), supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF) and by the Portuguese Foundation for Science and Technology (FCT) (FCOMP-01-0124-FEDER-028695, FEDER, COMPETE, Ref. FCTPTDC/DTP-FTO/0130/2012). Pedro Mendes-Ferreira and Rui Adão thank FCT for their PhD grants (SFRH/BD/87714/2012 and SFRH/BD/96403/2013, respectively).
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Pulmonary arterial hypertension.pdf
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