Correlation between Interleukin-6 and Thrombin–Antithrombin III Complex Levels in Retinal Diseases

Abstract

PURPOSE:

This study aims to evaluate and correlate the levels of interleukin-6 (IL-6) and thrombin-antithrombin III complex (TAT) in the vitreous of patients with different vitreoretinal pathologies.

METHODS:

Vitreous samples were collected from 78 patients scheduled for pars plana vitrectomy at a tertiary medical center. Patients were divided by the underlying vitreoretinal pathophysiology, as follows: macular hole (MH)/epiretinal membrane (ERM) (n = 26); rhegmatogenous retinal detachment (RRD) (n = 32); and proliferative diabetic retinopathy (PDR) (n = 20). Levels of IL-6 and TAT were measured by enzyme-linked immunosorbent assay and compared among the groups.

RESULTS:

A significant difference was found in the vitreal IL-6 and TAT levels between the MH/ERM group and both the PDR and RRD groups (P < 0.001 for all). Diabetes was associated with higher IL-6 levels in the RRD group. Different relationships between the IL-6 and TAT levels were revealed in patients with different ocular pathologies.

CONCLUSION:

Our results imply that variations in vitreal TAT level may be attributable not only to an inflammatory reaction or blood-retinal barrier breakdown, but also to intraocular tissue-dependent regulation of thrombin.

KEYWORDS:

Blood–retinal barrier; coagulation; inflammation; interleukin-6; thrombin–antithrombin III; vitreoretinal pathology

PMID: 28632410

DOI:10.1080/02713683.2017.1313432

https://www.sechenov.ru/science_and_innovation/repo/?PAGEN_1=16#134840