PREPARATION AND EVALUATION OF EXTENDED RELEASE TABLETS OF VENLAFAXINE HYDROCHLORIDE

The present investigation is aimed at formulating and evaluating Extended release tablets of Venlafaxine Hcl using different polymers such as HPMC K4M, Eudragit RL-100.Venlafaxine Hydrochloride used for the management of major depressive disorder. Different concentrations of the polymers were taken. The physical mixture was evaluated prior to compression for determining the flow properties. These tablets were evaluated for weight variation, hardness, thickness, friability, content uniformity and in-vitro drug release profile. It was found that the formulation F3 containing HPMC K4M Polymer release 99% of drug In 24 hours time period and it is selected as a optimized formulation. Drug –Excipient interactions of pure drug and optimized formulations was carried out by using FTIR Study. Key words: Venlafaxine HCl, HPMC K4M,Eudragit RL-100.