DRUG INDUCED NEPHROTOXICITY: GENTAMYCIN VERSUS RIVAROXABAN IN ALBINO RAT MODEL

To compare the renal effects of Rivaroxaban and gentamycin in albino wistar rats this Experimental study was conducted in animal house Tando Jam Agricultural University and Pharmacology department Isra University Hyderabad from June 2015-December 2015. Male Albino wistar rats(n=30) randomly selected and purchased from Karachi and divided into 3 equal groups. Control Group (Group A), Gentamycin treated (Group B) and Rivaroxaban treated (Group C). A single daily dose of gentamycin (80mg/kg/day) was given by intra peritoneal route for 10 days and Rivaroxaban (10mg/kg/day). Blood samples were collected and analyzed for serum urea and creatinine on day 0 , 7and 14 under standard conditions using centrifuge and Hitachi analyzer. Data analysis was accomplished by using 21^st version of the    SPSS (Statistical Packages for Social Sciences) .The mean of weight, serum urea and creatinine of groups A, B and C, was compared by ANOVA. P-value <0.05 was considered as level of significance. We found Weight of study groups A, B and C at day 0 was             237.80±19.75, 249.10±23.59 and 239.90±20.76respectively with no significant difference (p-vale o.448) but the same was found significant at 7^th and 14^th days p-values 0.00002 and 0.00008 respectively. Similarly serum urea and creatinine were non -significant among all three groups initially but found highly significant after 7 and 14 days with p-values for urea 0.814, 0.00004 and 0.00003 and p-value for creatinine 0.367, 0.00001 and 0.00005 among groups A,B and C at days 0,7and14 respectively.

 Conclusion: Rivaroxaban is less nephrotoxic than gentamicin.

Key Words: Gentamicin, Rivaroxaban, Urea, Creatinine