HEPATIC CHANGES IN LIVER OF ALBINO RATS INDUCED BY MONOSODIUM GLUTAMATE AND HEPATO-PROTECTIVE ROLE OF GINKGO BILOBA

Background: To determine the histological Hepatic changes in liver of albino rats induced by monosodium glutamate and Hepato-protective role of ginkgo biloba.

Methods: 21 Albino Wistar rats were taken for this study and divided into 3 parallel groups (n=7 in each group). All the healthy adult Wistar rats with normal average weight (150-200g) and without any gross abnormality were selected for the study. All effected disease or any moribund rats were excluded. On 46 day after the completion of experiment  all rats were scarify and the Liver of wistar rats rapidly collected  and fixed in formaldehyde.

Results: Group of rats received MSG for 45 days shows changes of congestion of central vein in 7 out of seven, there also changes  in infiltration of leukocyte observed in 6 rats,  centrilobulor hemorrhagic necrosis see in all 7 rats, and only one animal observed with changes of hepatic fibrosis.

Conclusion: It is concluded that MSG have significant effects on histology of liver.

Keywords: Liver, monosodium glutamate, histological changes in the Liver.