TRANSPORT FUNCTION: WHICH CHOROID PLEXUS IS MORE ACTIVE?

The choroid plexus (CP) is present in brain ventricles. It is responsible for cerebrospinal fluid (CSF) secretion and various vital functions. Special proteins present in choroidal epithelium play important roles in CSF production and energy metabolism.This study aims to compare between the lateral and fourth ventricles CPs using monocarboxylate transporter 1 (MCT1), transport marker, to evaluate the functional activity of this tissue in the two regions.Ten adult male albino rats were used to study the histological features of the CPs and to study the functional activity by quantitative immunohistochemical labeling with MCT1.Reactions intensities for MCT1 marker in the fourth ventricle CP was significantly higher with a wider spectrum of transport activity than those in the lateral ventricle. Both CPs displayed ?non-reactive? cells to this marker.The CP of the fourth ventricle had more functional activity than the CP of the lateral ventricle. Immunohistochemical detection of transport marker went along with findings of other histological and biochemical studies to define the CP as a highly dynamic structure with regional variations forming a continuum of one entity tissue capable of functional adaptation according to body needs.