A BRIEF REVIEW ON HUTCHINSON-GILFORD PROGERIA SYNDROME

Hutchinson-Gilford Progeria Syndrome (HGPS) was first documented in 1886 in the medical literature. A HGPS patient has the physical characteristics and appearances of an elderly individual. It is now clear that the syndrome results from the accumulation of a metabolite formed during processing of the mutated pre-lamin A protein. The purpose of this review is to increase the awareness of Hutchinson-Gilford Progeria Syndrome and its conditions and discuss the new therapeutic approaches among worldwide.

Key words: Hutchinson-Gilford Progeria Syndrome, bone deformation, pre-lamin A, Progeroid syndromes.