SERUM PROTEIN THIOL LEVELS IN PATIENT WITH HOSPITAL-ACQUIRED ACUTE KIDNEY INJURY

The basic purpose of this study is to analyze the antioxidants in acute kidney injury (AKI) patients and regulate whether the levels of serum protein thiols are linked with all-cause 90 days patient’s mortality associated with hospital-acquired AKI.

As per the RIFLE (Risk, Injury, Failure, Loss, and ESRD) criteria hospital-acquired AKI 160 patients were registered in this research. As controls, from 160 patients 72 were critically ill patients without AKI and 72 sex and age-matched healthy subjects also registered. The levels of serum protein thiol were assessed in connection to all-cause AKI patients’ mortality.

The levels of serum protein thiol in the patients of AKI were lesser than those in normal/healthy persons (p=0.010). Levels of protein thiol represented a weaker but important positive correlation with levels of serum albumin. The 90-day overall rate of mortality was elevated in the patients of AKI with high levels of serum protein thiol as compared with those with low (p=0.032 by the test of log-rank).

According to Cox regression multivariate analysis, levels of serum protein thiol (p=0.031) were impartially linked with an overall mortality of 90 days after adjustment of sex, age, sepsis, and Chronic Health Evaluation II scores.

It was found that hospital-acquired AKI patients have considerably low levels of serum protein thiol. Increased levels of protein thiol are linked with 90-day inclusive mortality in hospital-acquired AKI.

Keywords: Serum Protein Thiols, Mortality, Acute Kidney Injury