A Review and Recent Update on LCMS
Creators
- 1. Department of Quality Assurance, Y B Chavan Collage of Pharmacy, India
- 2. Department Of Pharmaceutical Chemistry, School Of Pharmacy SRTM Camps, Swami Ramananth Teerth Marathwada University, India
Description
Liquid Chromatography/Mass spectrum analysis (LC/MS) is quick developing and it’s the
popular tool of liquid chromatographers. Liquid chromatography-mass spectrum analysis
(LC-MS/MS) could be a technique that uses liquid natural process (or HPLC) with the mass
spectrometry. It's AN analytical chemistry technique that mixes the physical separation
capabilities of liquid natural process (or HPLC) with the mass analysis capabilities of mass
spectrum analysis. (LC-MS/MS) is commonly utilized in laboratories for the qualitative and
measurement of drug substances, drug product and biological samples. it's been persistently
utilized in drug development at many alternative stages as well as Metabolic Stability
Screening, Metabolite Identification moreover as in vivo Drug Screening, Impurity
Identification, amide Mapping, Glycoprotein Mapping, Natural product Dereplication, Bioaffinity
Screening. LC-MS is now with success applied to routine analysis in several areas, as
well as therapeutic drug monitoring (TDM), clinical and rhetorical pharmacological
medicine moreover as doping management. This advancement in LCMS was originally and
still is oil-fired by the necessity for a lot of powerful analytical and bio-analytical techniques
that may accurately and exactly discriminate target analytes from high quality mixtures in a
very sensitive and selective means. With recent advancement in instrumentation, the
employment of liquid natural process (LC) and mass spectrometry (MS) has become a strong
two-dimensional (2D) combined technology.
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References
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Subjects
- Pharmacy
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