PARTIAL ORAL VERSUS INTRAVENOUS ANTIBIOTIC TREATMENT OF ENDOCARDITIS

All those patients who have ineffective endocarditis, specifically on their heart’s left side are particularly given the IV antibiotics agents. A specific shift from IV to oral antibiotics to stable condition’s patients once may provide better results in effectiveness and for the curative measure.

In this research, we assigned, randomly, four hundred adults, all in the steady situation who had left the side of heart endocarditis by Streptococcus, Staphylococcus aureus, coagulase-negative staphylococci and/or enterococcus feacalis and finally those who are treated through IV antibiotics. IV treatment is given to 199 patients and orally administrated patients are 201. Basic outcome of mortality, embolic events, cardiac surgery or relapse of bacteremia has been completed till six months after antibiotic treatment.

After the process of randomization, the treatment of antibiotic was accomplished after a median 19 days (from 14 to 25 days interquartile range) in the group which treated through intravenously and after 17 days, in the group which is treated by orally (P=0.48). The basic outcome happened at 12.1% rate in 24 patients with confidence interval 95% (3.4to9.6 P = 0.40).

In all those patients who suffered left side of heart endocarditis in a steady condition, a change in antibiotic treatment orally was non-inferior to sustained IV antibiotic treatment.

Keywords:  Antibiotic treatment, oral, intravenous, endocarditis, heart.