Plasma circulating microRNA-expression quantitative trait loci (eQTLs) data in the Rotterdam Study

The dataset contains GWAS summary statistics for 2,083 plasma circulating microRNAs, obtained from nearly 2,178 participants of the Rotterdam Study. The dataset includes three files, as outlined below:

File1: SNP_reference_file_maf0.01_Rsq0.7.txt

A reference file for SNPs with good imputation quality (Rsq > 0.7)  and minor allele frequency > 0.01 among participants included in our GWAS in the Rotterdam Study (N=2,178). The headers are:

SNP: rsID

chr: chromosome number according to GRCh37

bp: basepair position according to GRCh37

effect_allele: effect allele

other_allele: other allele

eaf: effect allele frequency

File2: miReQTLs_1e-5_maf0.01_Rsq0.7.txt

Summary statistics for all SNPs significantly associated with 2083 miRNAs (p-value < 1e-5), filtered by minor allele frequency > 0.01 and Rsq > 0.7. The headers are:

SNP: rsID

beta: effect estimate

se: standard error

pval: p-value

miRNA: miRNA ID

File3: miReQTLs_nominal_sig.csv.gz

Summary statistics for all SNPs nominally associated with 2083 miRNAs (p-value < 0.05). The headers are:

RSID: SNP ID

p-value: p-value

phenotype: miRNA

SE: standard error

BETA: effect estimate

The SNP allelic information and frequency can be found in the reference file (File1). 

For more information, please contact: m.ghanbari@erasmusmc.nl