Published September 3, 2024
| Version v1
Journal article
Open
Alleviative effects of combined topical melatonin and rutin on imiquimod-induced psoriasis mouse model
Authors/Creators
- 1. Al-Nahrain University, Baghdad, Iraq
- 2. Al-Mustaqbal University, Babylon, Iraq
Description
Background: Psoriasis is a longstanding autoimmune dermatosis with thickened, reddish-brown, and flaking skin lesions. Melatonin is an indolamine hormone exhibiting antioxidant, anti-inflammatory, and anti-proliferative actions. Rutin is a nutritional flavonoid possessing antioxidative, anti-inflammatory, and immunomodulatory properties.
Aim: To explore the potential anti-psoriatic activity of combined topical melatonin and rutin.
Methods: 70 albino mice were divided into 7 groups of 10 each. The impacts of clinical observation, histopathological examination, and biomarker analysis were estimated.
Results: Combined topical melatonin and rutin effectively diminished imiquimod-induced elevated PASI and Baker's scores and corrected histopathological aberrations. Diminished inflammatory indicators like TNF-α and IL-17A, angiogenic elements like VEGF, oxidative elements like MDA, and proliferative elements like Ki-67 were also noted.
Conclusion: Combined topical melatonin and rutin have profound anti-psoriatic effects.
Files
PHAR_article_128832.pdf
Files
(2.0 MB)
| Name | Size | Download all |
|---|---|---|
|
md5:4775a935d090d683941ef3a93b0b794a
|
1.8 MB | Preview Download |
|
md5:6c52a28b29c373c688dcb92c647bc90b
|
183.1 kB | Preview Download |
Additional details
References
- Abbas A, Abd A, Salman H, Abbas Z (2023) The Attenuated Effects of Cimifugin on Imiquimod-Induced Model of Psoriasis in Mice. Latin American Journal of Pharmacy 42(special issue): 362–369.
- Abed-Mansoor A, Abu-Raghif AR (2022) Attenuated effects of rivastigmine in induced cytokine storm in mice. Journal of Emergency Medicine. Trauma & Acute Care 2022(3): 12. https://doi.org/10.5339/jemtac.2022.ismc.12
- Abidi A, Ahmad F, Singh SK, Kumar A (2010) Study of reservoir effect of clobetasol propionate cream in an experimental animal model using histamine-induced wheal suppression test. Indian Journal of Dermatology 55(4): 329–333. https://doi.org/10.4103/0019-5154.74531
- Abu-Raghif AR, Qasim BJ, Abady AH, Sahib HB (2015) Effects of aqueous thyme extract against cisplatin induced nephrotoxicity in rabbits. International Journal of Pharmaceutical Sciences Review and Research 30(1): 190–194.
- Ahmad SB, Ali A, Bilal M, Rashid SM, Wani AB, Bhat RR, Rehman MU (2023) Melatonin and health: Insights of melatonin action, biological functions, and associated disorders. Cellular and Molecular Neurobiology 43(6): 2437–2458. https://doi.org/10.1007/s10571-023-01324-w
- Ahmed O, Farid A, Elamir A (2022) Dual role of melatonin as an anti-colitis and anti-extra intestinal alterations against acetic acid-induced colitis model in rats. Scientific Reports 12(1): 6344. https://doi.org/10.1038/s41598-022-10400-y
- Akinrinde A, Omotosho O, Adetiba R, Oyagbemi A, Omobowale T (2023) Rutin and melatonin ameliorate the gastrointestinal and hepatic injuries induced by oral lead acetate in rats. Iranian Journal of Toxicology 17(4): 50–60. https://doi.org/10.61186/IJT.17.4.50
- AL-Bairmani RJ, Kadhim HM (2023) Evaluation of anti-aging effects of gemfibrozil on d-galactose induced aging mouse model. International Journal of Drug Delivery Technology 13(3): 1011–1016. https://doi.org/10.25258/ijddt.13.3.40
- Al-Jabr KH, Alhumaidan LS, Alghamdi AA, Almutairi MSL, Alsubaihi AA, Alrasheedi SM, Alkhdairi A, Alzweihary AM, Alrasheedi MS, Alrasheedi KAM, Alrashdi MN (2024) Awareness of side effects of corticosteroids among users and nonusers in Saudi Arabia. Journal of Pharmacy & Bioallied Sciences 16(Suppl 2): S1612–s1618. https://doi.org/10.4103/jpbs.jpbs_925_23
- Al-Rasheed N, Faddah L, Al-Rasheed N, Bassiouni YA, Hasan IH, Mahmoud AM, Mohamad RA, Yacoub HI (2016) Protective effects of silymarin, alone or in combination with chlorogenic acid and/or melatonin, against carbon tetrachloride-induced hepatotoxicity. Pharmacognosy Magazine 12(Suppl 3): S337–S345. https://doi.org/10.4103/0973-1296.185765
- Al-Rasheed NM, Fadda L, Attia HA, Sharaf IA, Mohamed AM, Al-Rasheed NM (2017) Pulmonary prophylactic impact of melatonin and/or quercetin: A novel therapy for inflammatory hypoxic stress in rats %J. Acta Pharmaceutica 67(1): 125–135. https://doi.org/10.1515/acph-2017-0010
- Ali KH, Al-Jawad FH, Kadhim HM (2021) The possible hepatoprotective effects of combination of an oral krill oil and silymarin against carbon tetrachloride (Ccl4)-induced liver fibrosis/ injury in white albino rats: Histopathological, and biochemical studies. International Journal of Drug Delivery Technology 11(3): 827–833. https://doi.org/10.25258/ijddt.11.3.29
- Almudaris SA, Gatea FK (2024) Effects of topical Ivermectin on imiquimod-induced Psoriasis in mouse model – Novel findings. Pharmacia 71: 1–14. https://doi.org/10.3897/pharmacia.71.e114753
- Alshanwani AR, Shaheen S, Faddah LM, Alhusaini AM, Ali HM, Hasan I, Hagar H, Ahmed R, Alharbi FMB, AlHarthii A (2020) Manipulation of Quercetin and Melatonin in the Down-Regulation of HIF-1α, HSP-70 and VEGF Pathways in Rat's Kidneys Induced by Hypoxic Stress. Dose-Response 18(3): 1559325820949797. https://doi.org/10.1177/1559325820949797
- Alzubaidy FM, Almuttairi RS, Bash AA (2016) The effects of yasmin on the histology and histochemistry of liver and kidney in rabbits. International Journal of PharmTech Research 9(11): 246–251.
- ALzubaidy FM, Bash AA, Jasim R (2020) Study the effect of gabapentin on the histology of some organs of male rats. Systematic Reviews in Pharmacy 11(9). https://doi.org/10.31838/srp.2020.9.16
- Amaral FGD, Cipolla-Neto J (2018) A brief review about melatonin, a pineal hormone. Archives of Endocrinology and Metabolism 62(4): 472–479. https://doi.org/10.20945/2359-3997000000066
- Amaretti A, Raimondi S, Leonardi A, Quartieri A, Rossi M (2015) Hydrolysis of the rutinose-conjugates flavonoids rutin and hesperidin by the gut microbiota and bifidobacteria. Nutrients 7(4): 2788–2800. https://doi.org/10.3390/nu7042788
- Atarbashe RK, Abu-Raghif A (2020) The therapeutic effects of ambrisentan on experimentally induced colitis in a male rat's models. Annals of Tropical Medicine & Public Health 23(4): 90–99. https://doi.org/10.36295/ASRO.2020.23411
- Attarbashee RK, Mammdoh JK, Al-Kazzaz SG (2023) The protective effect of bosentan on methotrexate-induced oral mucositis in rats. Iraqi Journal of Veterinary Sciences 37(3): 629–635. https://doi.org/10.33899/IJVS.2023.135827.2536
- Aysun H, Burcu B (2018) An overview of melatonin as an antioxidant molecule: a biochemical approach Melatonin molecular biology, clinical and pharmaceutical approaches. IntechOpen 5: 59–85. https://doi.org/10.5772/intechopen.79421
- Baker BS, Fry LJBJoD (1992) The immunology of psoriasis. British Journal of Dermatology 126(1): 1–9. https://doi.org/10.1111/j.1365-2133.1992.tb08394.x
- Bash AA, Abd AKH (2020) Effect of Salix alba barks on experimentally induced obesity in rats. Annals of Tropical Medicine and Public Health 23(5): 421–434. https://doi.org/10.36295/ASRO.2020.23515
- Blagov A, Sukhorukov V, Guo S, Zhang D, Eremin I, Orekhov A (2023) The role of oxidative stress in the induction and development of psoriasis. Frontiers in Bioscience-Landmark 28(6): 118. https://doi.org/10.31083/j.fbl2806118
- Chen W-C, Wen C-H, Wang M, Xiao Z-D, Zhang Z-Z, Wu C-L, Wu R (2023) IL-23/IL-17 immune axis mediates the imiquimod-induced psoriatic inflammation by activating ACT1/TRAF6/TAK1/NF-κB pathway in macrophages and keratinocytes. The Kaohsiung Journal of Medical Sciences 39(8): 789–800. https://doi.org/10.1002/kjm2.12683
- Choi JK, Kim SH (2013) Rutin suppresses atopic dermatitis and allergic contact dermatitis. Experimental Biology and Medicine (Maywood) 238(4): 410–417. https://doi.org/10.1177/1535370213477975
- Cordiano R, Di Gioacchino M, Mangifesta R, Panzera C, Gangemi S, Minciullo PL (2023) Malondialdehyde as a potential oxidative stress marker for allergy-oriented diseases: An update. Molecules 28(16): 5979. https://doi.org/10.3390/molecules28165979
- De Jesus LB, Frota AF, de Araújo FM, Jesus RLC, Costa MFD, de Vasconcelos D, Gois MB, Baccan GC, da Silva VDA, Costa SL (2024) Effect of the Flavonoid Rutin on the Modulation of the Myenteric Plexuses in an Experimental Model of Parkinson's Disease. International Journal of Molecular Sciences 25(2): 1037. https://doi.org/10.3390/ijms25021037
- Del Rosso JQ (2020) Topical Corticosteroid Therapy for Psoriasis-A Review of Clobetasol Propionate 0.025% Cream and the Clinical Relevance of Penetration Modification. The Journal of Clinical and Aesthetic Dermatology 13(2): 22–29.
- Diotallevi F, Paolinelli M, Radi G, Offidani A (2022) Latest combination therapies in psoriasis: Narrative review of the literature. Dermatology and Therapy 35(10): e15759. https://doi.org/10.1111/dth.15759
- Dobrică EC, Cozma MA, Găman MA, Voiculescu VM, Găman AM (2022) The Involvement of Oxidative Stress in Psoriasis: A Systematic Review. Antioxidants 11(2): 282. https://doi.org/10.3390/antiox11020282
- Elbe H, Vardi N, Esrefoglu M, Ates B, Yologlu S, Taskapan C (2015) Amelioration of streptozotocin-induced diabetic nephropathy by melatonin, quercetin, and resveratrol in rats. Human and Experimental Toxicology 34(1): 100–113. https://doi.org/10.1177/0960327114531995
- Elmets CA, Korman NJ, Prater EF, Wong EB, Rupani RN, Kivelevitch D, Armstrong AW, Connor C, Cordoro KM, Davis DMR, Elewski BE, Gelfand JM, Gordon KB, Gottlieb AB, Kaplan DH, Kavanaugh A, Kiselica M, Kroshinsky D, Lebwohl M, Leonardi CL, Lichten J, Lim HW, Mehta NN, Paller AS, Parra SL, Pathy AL, Siegel M, Stoff B, Strober B, Wu JJ, Hariharan V, Menter A (2021) Joint AAD-NPF Guidelines of care for the management and treatment of psoriasis with topical therapy and alternative medicine modalities for psoriasis severity measures. Journal of the American Academy of Dermatology 84(2): 432–470. https://doi.org/10.1016/j.jaad.2020.07.087
- Enogieru AB, Haylett W, Hiss DC, Bardien S, Ekpo OE (2018) Rutin as a potent antioxidant: Implications for neurodegenerative disorders. Oxidative Medicine and Cellular Longevity 2018(1): 6241017. https://doi.org/10.1155/2018/6241017
- Escames G, López LC, Ortiz F, López A, García JA, Ros E, Acuña-Castroviejo D (2007) Attenuation of cardiac mitochondrial dysfunction by melatonin in septic mice. The FEBS Journal 274(8): 2135–2147. https://doi.org/10.1111/j.1742-4658.2007.05755.x
- Fareed M, Al-Qrimli AF (2024) Effects of topical petroleum ether and ethyl acetate fractions from grape seed extract on imiquimod-induced psoriasis like skin inflammation in mice. Al Mustansiriyah Journal of Pharmaceutical Sciences 24(2): 205–216. https://doi.org/10.32947/ajps.v24i2.1062
- Farhangian ME, Feldman SR (2015) Immunogenicity of biologic treatments for psoriasis: Therapeutic consequences and the potential value of concomitant methotrexate. American Journal of Clinical Dermatology 16(4): 285–294. https://doi.org/10.1007/s40257-015-0131-y
- Feldman SR, Yentzer BA (2009) Topical clobetasol propionate in the treatment of psoriasis. American Journal of Clinical Dermatology 10(6): 397–406. https://doi.org/10.2165/11311020-000000000-00000
- Gatti G, Lucini V, Dugnani S, Calastretti A, Spadoni G, Bedini A, Rivara S, Mor M, Canti G, Scaglione F, Bevilacqua A (2017) Antiproliferative and pro-apoptotic activity of melatonin analogues on melanoma and breast cancer cells. Oncotarget 8(40): 68338–68353. https://doi.org/10.18632/oncotarget.20124
- Guo J, Zhang H, Lin W, Lu L, Su J, Chen X (2023) Signaling pathways and targeted therapies for psoriasis. Signal Transduction and Targeted Therapy 8(1): 437. https://doi.org/10.1038/s41392-023-01655-6
- Gupta SK, Sharma HP, Das U, Velpandian T, Saklani R (2020) Effect of rutin on retinal VEGF, TNF-α, aldose reductase, and total antioxidant capacity in diabetic rats: Molecular mechanism and ocular pharmacokinetics. International Ophthalmology 40(1): 159–168. https://doi.org/10.1007/s10792-019-01165-x
- Gustafson CJ, Watkins C, Hix E, Feldman SR (2013) Combination Therapy in Psoriasis. American Journal of Clinical Dermatology 14(1): 9–25. https://doi.org/10.1007/s40257-012-0003-7
- Hameed MF, Kadhim EJ, Abu-Raghif AR (2020) Effect of topical artemisinin from artemisia annua in comparison with tacrolimus on induced atopic dermatitis in mice. Journal of Global Pharma Technology 12(2): 447–453.
- Hasan AM, Gatea FK (2024) Novel effect of topical Roquinimex and its combination with Clobetasol on an imiquimod-induced model of psoriasis in mice. Naunyn-Schmiedeberg's Archives of Pharmacology 397(7): 5219–5232. https://doi.org/10.1007/s00210-024-02947-6
- Hassan RF, Kadhim HM (2022a) Comparative effects of phenolic extract as an ointment dosage form in inducing wound healing in mice and β-sitosterol in experimentally induced acute wound healing in mice. Journal of Pharmaceutical Negative Results 13(3): 194–203. https://doi.org/10.47750/pnr.2022.13.03.031
- Hassan RF, Kadhim HM (2022b) Exploring the role of phenolic extract as an ointment dosage form in inducing wound healing in mice. Journal of Pharmaceutical Negative Results 13(3): 186–193. https://doi.org/10.47750/pnr.2022.13.03.030
- Hassan Z, Hassan T, Abu-Raghif A (2022) Evaluation the effectiveness of phenolic compound of salvia frigida on induced atopic dermatitis in experimental mice. Iraqi Journal of Pharmaceutical Sciences (P-ISSN 1683-3597 E-ISSN 2521-3512) 31 (1): 154–166. https://doi.org/10.31351/vol31iss1pp154-166
- Hassan ZY, Hassan TY, AbuRaghif AR (2023) Evaluation the effect of phytosterol fraction of chenopodium muralein comparison with tacrolimus on mice induced atopic dermatitis. Iraqi Journal of Pharmaceutical Sciences 32(1): 84–91. https://doi.org/10.31351/vol32iss1pp84-91
- Heidenreich R, Röcken M, Ghoreschi K (2009) Angiogenesis drives psoriasis pathogenesis. International Journal of Experimental Pathology 90(3): 232–248. https://doi.org/10.1111/j.1365-2613.2009.00669.x
- Heim M, Irondelle M, Duteil L, Cardot-Leccia N, Rocchi S, Passeron T, Tulic MK (2022) Impact of topical emollient, steroids alone or combined with calcipotriol, on the immune infiltrate and clinical outcome in psoriasis. Experimental Dermatology 31(11): 1764–1778. https://doi.org/10.1111/exd.14657
- Hosseinzadeh A, Javad-Moosavi SA, Reiter RJ, Hemati K, Ghaznavi H, Mehrzadi S (2018) Idiopathic pulmonary fibrosis (IPF) signaling pathways and protective roles of melatonin. Life Sciences 201: 17–29. https://doi.org/10.1016/j.lfs.2018.03.032
- Huang T-H, Lin C-F, Alalaiwe A, Yang S-C, Fang J-Y (2019) Apoptotic or antiproliferative activity of natural products against keratinocytes for the treatment of psoriasis. International Journal of Molecular Sciences 20(10): 2558. https://doi.org/10.3390/ijms20102558
- Huang S-H, Hong Z-J, Chen M-F, Tsai M-W, Chen S-J, Cheng C-P, Sytwu H-K, Lin G-J (2024) Melatonin inhibits the formation of chemically induced experimental encapsulating peritoneal sclerosis through modulation of T cell differentiation by suppressing of NF-κB activation in dendritic cells. International Immunopharmacology 126: 111300. https://doi.org/10.1016/j.intimp.2023.111300
- Iova GM, Calniceanu H, Popa A, Szuhanek CA, Marcu O, Ciavoi G, Scrobota I (2021) The antioxidant effect of curcumin and rutin on oxidative stress biomarkers in experimentally induced periodontitis in hyperglycemic wistar Rats. Molecules 26(5): 1332. https://doi.org/10.3390/molecules26051332
- Jahan S, Munir F, Razak S, Mehboob A, Ain QU, Ullah H, Afsar T, Shaheen G, Almajwal A (2016) Ameliorative effects of rutin against metabolic, biochemical and hormonal disturbances in polycystic ovary syndrome in rats. Journal of Ovarian Research 9(1): 86. https://doi.org/10.1186/s13048-016-0295-y
- Janjetovic Z, Jarrett SG, Lee EF, Duprey C, Reiter RJ, Slominski AT (2017) Melatonin and its metabolites protect human melanocytes against UVB-induced damage: Involvement of NRF2-mediated pathways. Scientific Reports 7(1): 1274. https://doi.org/10.1038/s41598-017-01305-2
- Jawad MJ, Rasool MI, Owadh HK, Hassan SM (2022) Anti-oxidant effect of infliximab and DMF during ischemia reperfusion induce liver injury in male rat. Journal of Pharmaceutical Negative Results 13(3): 685–689. https://doi.org/10.47750/pnr.2021.13.03.103
- Jaworek AK, Szepietowski JC, Hałubiec P, Wojas-Pelc A, Jaworek J (2021) Melatonin as an antioxidant and immunomodulator in atopic dermatitis—A new look on an old story: A review. Antioxidants 10(8): 1179. https://doi.org/10.3390/antiox10081179
- Jiang Y, Chen Y, Yu Q, Shi Y (2023) Biologic and small-molecule therapies for moderate-to-severe psoriasis: Focus on psoriasis comorbidities. BioDrugs 37(1): 35–55. https://doi.org/10.1007/s40259-022-00569-z
- Jung KH, Hong SW, Zheng HM, Lee DH, Hong SS (2009) Melatonin downregulates nuclear erythroid 2-related factor 2 and nuclear factor-kappaB during prevention of oxidative liver injury in a dimethylnitrosamine model. Journal of Pineal Research 47(2): 173–183. https://doi.org/10.1111/j.1600-079X.2009.00698.x
- Kadam DP, Suryakar AN, Ankush RD, Kadam CY, Deshpande KH (2010) Role of oxidative stress in various stages of psoriasis. Indian Journal of Clinical Biochemistry 25(4): 388–392. https://doi.org/10.1007/s12291-010-0043-9
- Kadhim H, Gatea F, Raghif AA, Ali K (2022) Role of topical ritodrine hydrochloride in experimentally induced hypertrophic scar in rabbits. Iraqi Journal of Pharmaceutical Sciences (P-ISSN 1683-3597 E-ISSN 2521-3512) 31(2): 260–270. https://doi.org/10.31351/vol31iss2pp260-270
- Kakarala CL, Hassan M, Belavadi R, Gudigopuram SVR, Raguthu CC, Gajjela H, Kela I, Sange I (2021) Beyond the skin plaques: Psoriasis and its cardiovascular comorbidities. Cureus 13(11): e19679. https://doi.org/10.7759/cureus.19679
- Kamal S, Khadhim H (2021) Effects of Irbesartan in induced Parkinson's disease in mice. International Journal of Pharmaceutical Quality Assurance 12(1): 31–39. https://doi.org/10.25258/ijpqa.12.1.5
- Khafaji AWM, Al-Zubaidy AAK, Farhood IG, Salman HR (2024) Ameliorative effects of topical ramelteon on imiquimod-induced psoriasiform inflammation in mice. Naunyn-Schmiedeberg's Archives of Pharmacology 397(8): 6231–6248. https://doi.org/10.1007/s00210-024-03017-7
- Khairutdinov VR, Mikhailichenko AF, Belousova IE, Kuligina ES, Samtsov AV, Imyanitov EN (2017) The role of intradermal proliferation of T-cells in the pathogenesis of psoriasis. Anais Brasileiros de Dermatologia 92(1): 41–44. https://doi.org/10.1590/abd1806-4841.20175765
- Khaleq MAA, Abu-Raghif AR, Kadhim SR (2015) Antibacterial activity of aloe vera essential oil against skin infection with Staphylococcus aureus: In vitro and in vivo studies. International Journal of Pharmaceutical Sciences Review and Research 33(2): 192–197.
- Krueger J, Puig L, Thaçi D (2022) Treatment options and goals for patients with generalized pustular psoriasis. American Journal of Clinical Dermatology 23(1): 51–64. https://doi.org/10.1007/s40257-021-00658-9
- Langley A, Beecker J (2018) Management of common side effects of apremilast. Journal of Cutaneous Medicine and Surgery 22(4): 415–421. https://doi.org/10.1177/1203475417748886
- Leyva-López N, Gutierrez-Grijalva EP, Ambriz-Perez DL, Heredia JB (2016) Flavonoids as Cytokine Modulators: A Possible Therapy for Inflammation-Related Diseases. International Journal of Molecular Sciences 17(6): 921. https://doi.org/10.3390/ijms17060921
- Li Q, Qiu Y, Mao M, Lv J, Zhang L, Li S, Li X, Zheng X (2014) Antioxidant mechanism of Rutin on hypoxia-induced pulmonary arterial cell proliferation. Molecules 19(11): 19036–19049. https://doi.org/10.3390/molecules191119036
- Lin LW, Wang SW, Huang WC, Huynh TK, Lai CY, Ko CY, Fong YC, Lee JJ, Yang SF, Tang CH (2023) Melatonin inhibits vegf-induced endothelial progenitor cell angiogenesis in neovascular age-related macular degeneration. Cells 12(5): 799. https://doi.org/10.3390/cells12050799
- Liu Y, Huang W, Ji S, Wang J, Luo J, Lu B (2022) Sophora japonica flowers and their main phytochemical, rutin, regulate chemically induced murine colitis in association with targeting the NF-κB signaling pathway and gut microbiota. Food Chemistry 393: 133395. https://doi.org/10.1016/j.foodchem.2022.133395
- Luo DQ, Wu HH, Zhao YK, Liu JH, Wang F (2016) Original research: Different imiquimod creams resulting in differential effects for imiquimod-induced psoriatic mouse models. Experimental Biology and Medicine (Maywood) 241(16): 1733–1738. https://doi.org/10.1177/1535370216647183
- Ma Q, Reiter RJ, Chen Y (2020) Role of melatonin in controlling angiogenesis under physiological and pathological conditions. Angiogenesis 23(2): 91–104. https://doi.org/10.1007/s10456-019-09689-7
- Mahdi ZA, Hussain AM, Alblesh HA (2024) Histopathological and immunological effects of nebivolol 5% topical cream in mice model of imiquimod-induced psoriasis. Al-Rafidain Journal of Medical Sciences [ISSN 2789-3219] 6(1): 133–141. https://doi.org/10.54133/ajms.v6i1.527
- Mao J, Ma X (2022) Bioinformatics Identification of Ferroptosis‐Associated Biomarkers and Therapeutic Compounds in Psoriasis. Journal of Oncology 2022(1): 3818216. https://doi.org/10.1155/2022/3818216
- Mascaraque C, Aranda C, Ocón B, Monte MJ, Suárez MD, Zarzuelo A, Marín JJ, Martínez-Augustin O, de Medina FS (2014) Rutin has intestinal antiinflammatory effects in the CD4+ CD62L+ T cell transfer model of colitis. Pharmacological Research 90: 48–57. https://doi.org/10.1016/j.phrs.2014.09.005
- Mateu-Arrom L, Puig L (2024) Choosing the right biologic treatment for moderate-to-severe plaque psoriasis: The impact of comorbidities. Expert Review of Clinical Pharmacology 17(4): 363–379. https://doi.org/10.1080/17512433.2024.2340552
- Mekkey SM, Abu Raghif AR, Alkafaji HA-R, Hadi NR (2020) The anti-parkinson effects of liraglutide in rat model of rotenone induced parkinsonism. International Journal of Pharmaceutical Research [09752366] 12 (2): 3695–3706. https://doi.org/10.31838/ijpr/2020.SP2.449
- Monteiro K, Shiroma ME, Damous LL, Simões MJ, Simões RDS, Cipolla-Neto J, Baracat EC, Soares Jr JM (2024) Antioxidant actions of melatonin: A systematic review of animal studies. Antioxidants 13(4): 439. https://doi.org/10.3390/antiox13040439
- Morvaridzadeh M, Sadeghi E, Agah S, Nachvak SM, Fazelian S, Moradi F, Persad E, Heshmati J (2020) Effect of melatonin supplementation on oxidative stress parameters: A systematic review and meta-analysis. Pharmacological Research 161: 105210. https://doi.org/10.1016/j.phrs.2020.105210
- Muñoz-Jurado A, Escribano BM, Caballero-Villarraso J, Galván A, Agüera E, Santamaría A, Túnez I (2022) Melatonin and multiple sclerosis: Antioxidant, anti-inflammatory and immunomodulator mechanism of action. Inflammopharmacology 30(5): 1569–1596. https://doi.org/10.1007/s10787-022-01011-0
- Muvhulawa N, Dludla PV, Ziqubu K, Mthembu SXH, Mthiyane F, Nkambule BB, Mazibuko-Mbeje SE (2022) Rutin ameliorates inflammation and improves metabolic function: A comprehensive analysis of scientific literature. Pharmacological Research 178: 106163. https://doi.org/10.1016/j.phrs.2022.106163
- Naji ME, Gatea FK, Ali KA, Raghif ARA (2022) Effect of convolvulus arvensis ethanolic extract on testosterone-induced alopecia in mice. International Journal of Drug Delivery Technology 12(3): 1070–1075. https://doi.org/10.25258/ijddt.12.3.24
- Nasiri F, Kismali G, Alpay M, Kosova F, Cakir DU, Sel T (2016) Abstract 2177: Rutin enhances the antiproliferative effect of 5-FU and oxaliplatin in colon cancer cells. Cancer Research 76(14, Supplement): 2177–2177. https://doi.org/10.1158/1538-7445.Am2016-2177
- Negi G, Kumar A, Sharma SS (2011) Melatonin modulates neuroinflammation and oxidative stress in experimental diabetic neuropathy: Effects on NF-κB and Nrf2 cascades. Journal of Pineal Research 50(2): 124–131. https://doi.org/10.1111/j.1600-079X.2010.00821.x
- Obaid KA (2024) Anti-angiogenesis efficacy of the aqueous extract of Allium sativum and its combination with melatonin in an animal model: In vivo and ex vivo studies. Pharmacia 71: 1–8. https://doi.org/10.3897/pharmacia.71.e125298
- Obaidi I, Alzubaidi FA, Bash AA, Fadheel QJ, Al-Humadi HW, Liu J (2024) Novel anticancer mechanisms of JinYingZi-derived oleanolic acid against renal cell carcinoma: an in silico analysis. Review of Clinical Pharmacology and Pharmacokinetics, International Edition 38: 157–160. https://doi.org/10.61873/KZWS3688
- Oubaid EN, Abu-Raghif AR, Al-Sudani IM (2023) Phytochemical screening and antioxidant activity of uncaria tomentosa extract: in vitro: and: In vivo: Studies. Medical Journal of Babylon 20(1): 136–142. https://doi.org/10.4103/MJBL.MJBL_310_22
- Pandey R, Al-Nuaimi Y, Mishra RK, Spurgeon SK, Goodfellow M (2021) Role of subnetworks mediated by $$\hbox {TNF}\alpha$$, IL-23/IL-17 and IL-15 in a network involved in the pathogenesis of psoriasis. Scientific Reports 11(1): 2204. https://doi.org/10.1038/s41598-020-80507-7
- Petkova VB, Dimitrov MV, Nikolova IN, Voycheva CC, Valchanova VG, Andreevska KG (2014) Psoriasis influence on the patients' quality of life. World Journal of Pharmacy and Pharmaceutical Sciences 3(8): 1942–1948.
- Philipp S, Wilsmann-Theis D, Weyergraf A, Rotterdam S, Frambach Y, Gerdes S, Mössner R (2012) Combination of adalimumab with traditional systemic antipsoriatic drugs - a report of 39 cases. Journal der Deutschen Dermatologischen Gesellschaft 10(11): 821–837. https://doi.org/10.1111/j.1610-0387.2012.07976.x
- Pierozan P, Jernerén F, Ransome Y, Karlsson O (2017) The Choice of Euthanasia Method Affects Metabolic Serum Biomarkers. Basic & Clinical Pharmacology & Toxicology 121(2): 113–118. https://doi.org/10.1111/bcpt.12774
- Ridha-Salman H, Shihab EM, Hasan HK, Abbas AH, Khorsheed SM, Ayad Fakhri S (2024) Mitigative effects of topical norfloxacin on an imiquimod-induced murine model of psoriasis. ACS Pharmacology & Translational Science 7(9): 1–16. https://doi.org/10.1021/acsptsci.4c00152
- Sahi FM, Masood A, Danawar NA, Mekaiel A, Malik BH (2020) Association between psoriasis and depression: A traditional review. Cureus 12(8): e9708. https://doi.org/10.7759/cureus.9708
- Salman HR, Al-Khafaji BA, Mohammed NJ (2013) Effect of Apium graveolens leaves and stalks in reducing the side effects of doxorubicin in male rabbits. Medical Journal of Babylon 10(1): 46–74.
- Salman HR, Al-Zubaidy AA, Abbas AH, Zigam QA (2024a) The ameliorative effects of topical gemifloxacin alone or in combination with clobetasol propionate on imiquimod-induced model of psoriasis in mice. Naunyn-Schmiedeberg's Archives of Pharmacology 397(1): 599–616. https://doi.org/10.1007/s00210-023-02629-9
- Salman HR, Alzubaidy AA, Abbas AH, Mohammad HA (2024b) Attenuated effects of topical vinpocetine in an imiquimod-induced mouse model of psoriasis. Journal of Taibah University Medical Sciences 19(1): 35–53. https://doi.org/10.1016/j.jtumed.2023.09.002
- Sami N, Feld Sdl (2021) 46 - Topical Retinoids. In: Wolverton SE (Ed.) Comprehensive Dermatologic Drug Therapy (4th edn.). Elsevier, 528–540.e524. https://doi.org/10.1016/B978-0-323-61211-1.00046-2
- Sandra RM, Juan CCD Isaí Martínez‐ T, Sonia MPT, Mario ECD (2017) Psoriatic Animal Models Developed for the Study of the Disease. In: Anca C (Ed.) Psoriasis. IntechOpen, Rijeka, Ch. 5. https://doi.org/10.5772/intechopen.68305
- Satari A, Ghasemi S, Habtemariam S, Asgharian S, Lorigooini Z (2021) Rutin: A flavonoid as an effective sensitizer for anticancer therapy; insights into multifaceted mechanisms and applicability for combination therapy. Evidence-Based Complementary and Alternative Medicine 2021: 9913179. https://doi.org/10.1155/2021/9913179
- Schön MP (2019) Adaptive and innate immunity in psoriasis and other inflammatory disorders. Frontiers in Immunology 10: 1764. https://doi.org/10.3389/fimmu.2019.01764
- Shen Z, Jiang J, Zhou X, Tan Q, Yan S, Wu X, Pi J, Wang H, Yang H, Luo X (2024) Melatonin Attenuates Imiquimod-Induced Psoriasis-Like Inflammation and Restores the Th17/Treg Immune Balance. Inflammation. https://doi.org/10.1007/s10753-024-02023-4
- Shihab EM, Kadhim HM (2023) The impact of carvedilol on organ index, inflammatory mediators, oxidative stress parameters and skin markers in d-galactose-induced aging mice. International Journal of Drug Delivery Technology 13(3): 1017–1023. https://doi.org/10.25258/ijddt.13.3.41
- Shihab EM, Kadhim HM, Shahooth SS (2024) Dapagliflozin mitigates oxidative stress, inflammatory, and histopathological markers of aging in mice. Journal of Medicine and Life 17(2): 157–163. https://doi.org/10.25122/jml-2023-0343
- Singh TP, Schön MP, Wallbrecht K, Gruber-Wackernagel A, Wang XJ, Wolf P (2013) Involvement of IL-9 in Th17-associated inflammation and angiogenesis of psoriasis. PLoS ONE 8(1): e51752. https://doi.org/10.1371/journal.pone.0051752
- Sirotkin AV (2024) Positive effects of rutin on female reproduction. Reproduction in Domestic Animals 59(2): e14540. https://doi.org/10.1111/rda.14540
- Sirotkin AV, Kolesarova A (2022) Chapter 4 - Plant molecules and their influence on health and female reproduction. In: Sirotkin AV, Kolesarova A (Eds) Environmental Contaminants and Medicinal Plants Action on Female Reproduction. Academic Press, 245–399. https://doi.org/10.1016/B978-0-12-824292-6.00004-0
- Snehasis N, Zafar S, Herve N, Siri P, Haji Ali K (2024) Efficacy and safety of various drug combinations in treating plaque Psoriasis: A meta-analysis. F1000 Research 13: 453. https://doi.org/10.12688/f1000research.149172.1
- Sonehara NM, Lacerda JZ, Jardim-Perassi BV, de Paula Jr R, Moschetta-Pinheiro MG, Souza YST, de Andrade JCJ, De Campos Zuccari DAP (2019) Melatonin regulates tumor aggressiveness under acidosis condition in breast cancer cell lines. Oncology Letters 17(2): 1635–1645. https://doi.org/10.3892/ol.2018.9758
- Sreya R, Nene S, Pathade V, Singh SB, Srivastava S (2023) Emerging trends in combination strategies with phototherapy in advanced psoriasis management. Inflammopharmacology 31(4): 1761–1778. https://doi.org/10.1007/s10787-023-01257-2
- Takeshita J, Grewal S, Langan SM, Mehta NN, Ogdie A, Van Voorhees AS, Gelfand JM (2017) Psoriasis and comorbid diseases: Epidemiology. Journal of the American Academy of Dermatology 76(3): 377–390. https://doi.org/10.1016/j.jaad.2016.07.064
- Uva L, Miguel D, Pinheiro C, Antunes J, Cruz D, Ferreira J, Filipe P (2012) Mechanisms of action of topical corticosteroids in psoriasis. International Journal of Endocrinology 2012: 561018. https://doi.org/10.1155/2012/561018
- Van Der Fits L, Mourits S, Voerman JS, Kant M, Boon L, Laman JD, Cornelissen F, Mus A-M, Florencia E, Prens EP (2009) Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23/IL-17 axis. The Journal of Immunology 182(9): 5836–5845. https://doi.org/10.4049/jimmunol.0802999
- Veneroso C, Tuñón MJ, González-Gallego J, Collado PS (2009) Melatonin reduces cardiac inflammatory injury induced by acute exercise. Journal of Pineal Research 47(2): 184–191. https://doi.org/10.1111/j.1600-079X.2009.00699.x
- Vijayapoopathi S, Ramamoorthy R, Meganathan J, Kalaiyazhagan A, Bhuvarahamurthy S, Venugopal B (2023) Nutraceutical combination ameliorates imiquimod-induced psoriasis in mice. Chemical Biology & Drug Design 102(6): 1578–1587. https://doi.org/10.1111/cbdd.14350
- Wang M, Ma X, Gao C, Luo Y, Fei X, Zheng Q, Ma X, Kuai L, Li B, Wang R, Song J (2023) Rutin attenuates inflammation by downregulating AGE-RAGE signaling pathway in psoriasis: Network pharmacology analysis and experimental evidence. International Immunopharmacology 125 (Pt A): 111033. https://doi.org/10.1016/j.intimp.2023.111033
- Wroński A, Gęgotek A, Skrzydlewska E (2023) Protein adducts with lipid peroxidation products in patients with psoriasis. Redox Biology 63: 102729. https://doi.org/10.1016/j.redox.2023.102729
- Xie J, Huang S, Huang H, Deng X, Yue P, Lin J, Yang M, Han L, Zhang D-K (2021) Advances in the application of natural products and the novel drug delivery systems for psoriasis. Frontiers in Pharmacology 12: 644952–644952. https://doi.org/10.3389/fphar.2021.644952
- Yang J, Guo J, Yuan J (2008) In vitro antioxidant properties of rutin. Lebensmittel-Wissenschaft + Technologie 41(6): 1060–1066. https://doi.org/10.1016/j.lwt.2007.06.010
- Yang J, Lee H, Sung J, Kim Y, Jeong HS, Lee J (2019) Conversion of rutin to quercetin by acid treatment in relation to biological activities. Preventive Nutrition and Food Science 24(3): 313–320. https://doi.org/10.3746/pnf.2019.24.3.313
- Yazici AC, Tursen U, Apa DD, Ikizoglu G, Api H, Baz K, Tasdelen B (2005) The changes in expression of ICAM-3, Ki-67, PCNA, and CD31 in psoriatic lesions before and after methotrexate treatment. Archives of Dermatological Research 297(6): 249–255. https://doi.org/10.1007/s00403-005-0602-8
- Yi T, Zhang W, Hua Y, Xin X, Wu Z, Li Y, Wen C, Fan Y, Ji J, Xu L (2024) Rutin alleviates lupus nephritis by inhibiting T cell oxidative stress through PPARγ. Chemico-Biological Interactions 394: 110972. https://doi.org/10.1016/j.cbi.2024.110972
- Zhang L, Zhang J-T, Huang Y, Zhou G-K, Zhou Y, Yang J-P, Liu T (2022) Melatonin attenuates acute and chronic itch in mice: The antioxidant and anti-inflammatory effects of melatonin receptors. Annals of Translational Medicine 10(18): 972. https://doi.org/10.21037/atm-22-3804
- Zhang L, Huang Z, Xuan J, Yang L, Zhao T, Peng W (2024) Anti-psoriatic activity of black, green and white tea extracts from southeastern china. Molecules 29(6): 1279. https://doi.org/10.3390/molecules29061279
- Zhao C-N, Wang P, Mao Y-M, Dan Y-L, Wu Q, Li X-M, Wang D-G, Davis C, Hu W, Pan H-F (2019) Potential role of melatonin in autoimmune diseases. Cytokine & Growth Factor Reviews 48: 1–10. https://doi.org/10.1016/j.cytogfr.2019.07.002
- Zhu B, Jing M, Yu Q, Ge X, Yuan F, Shi L (2022) Treatments in psoriasis: from standard pharmacotherapy to nanotechnology therapy. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii 39(3): 460–471. https://doi.org/10.5114/ada.2021.108445