Vitamin D and hypertension

Pawlicka Marta, Fałkowska Urszula, Bałabuszek Kamil, Radzka Agnieszka, Mroczek Anna, Bednarski Jerzy. Vitamin D and hypertension. Journal of Education, Health and Sport. 2018;8(9):219-228. eISNN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.1346149

http://ojs.ukw.edu.pl/index.php/johs/article/view/5823

https://pbn.nauka.gov.pl/sedno-webapp/works/873793

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1223 Journal of Education, Health and Sport eissn 2391-8306 7

© The Authors 2018;

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Received: 02.06.2018. Revised: 18.06.2018. Accepted: 16.08.2018.

Vitamin D and hypertension

Marta Pawlicka¹, Urszula Fałkowska¹, Kamil Bałabuszek¹, Agnieszka Radzka¹, Anna Mroczek¹, Jerzy Bednarski²

1 Student Research Circle at the Department of Epidemiology and Clinical Research Methodology, Medical University of Lublin, Poland

2 Department of Human Anatomy, Chair of Human Anatomy, Medical University of Lublin, Poland

ORCID ID

Marta Pawlicka https://orcid.org/0000-0002-6631-979X

Urszula Fałkowska https://orcid.org/0000-0002-8561-8904

Kamil Bałabuszek https://orcid.org/0000-0002-1352-153X

Agnieszka Radzka https://orcid.org/0000-0002-3484-4602

Anna Mroczek https://orcid.org/0000-0003-0077-5343

Jerzy Bednarski https://orcid.org/0000-0002-0186-3268

Abstract

Introduction: Current epidemiological studies indicate, that insufficiency of vitamin D affects 50% of the population worldwide. 1α,25(OH)₂D – active form of vitamin D affects tissues and organs through vitamin D receptor (VDR). Attention to the role of vitamin D deficiency in hypertension development has been continuously increased during recent decades.

The aim of the study: The purpose of this narrative systemic review was to analyse and summarize available data on role of vitamin D deficiency in hypertension development.

Material and method: Standard criteria were used to review the literature data. The search of articles in the PubMed and Google Scholar database was carried out using the following keywords: hypertension, calcitriol, vitamin D, 25-hydroxyvitamin D.

Description of the state of knowledge: Vitamin D influence blood pressure level through renin-angiotensin-aldosterone system (RAAS) and parathormone regulation. Studies conducted on animal model could explain possible mechanism of vitamin D influence on blood pressure control. However, clinical trial results are equivocal due to differences in sample size, heterogeneity of patient baseline characteristics, different vitamin D doses and study duration.

Summary: Further research is needed to confirm the role of vitamin D in hypertension development.

Key words: vitamin D, hypertension, blood pressure, cholecalciferol