Published August 27, 2024
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Freeze-dried erythromycin nanocrystals: preparation, characterisation, antimicrobial activity, and aerodynamic properties
Authors/Creators
- 1. Isra University, Amman, Jordan
- 2. Middle East University, Amman, Jordan
Description
Background: This study aims to present the development and evaluation of freeze-dried erythromycin nanocrystals to enhance the solubility, dissolution rate, and antibacterial potency of erythromycin.
Results: Erythromycin nanocrystals had a particle size of 239.3 ± 24.6 nm with 0.17 ± 0.01 PDI. Erythromycin nanocrystals had significantly higher saturation solubility and a faster dissolution rate compared to coarse erythromycin. Nanocrystals showed a high drug content of 92.69% ± 2.82, while the aerodynamic characteristics demonstrated an emitted dose (ED%) of 83.68% ± 5.32 with a mass median aerodynamic diameter of 2.13 µm. Around half reduction of the minimum inhibitory concentrations were observed against P. aeruginosa and E. coli (125 µg and 62.5 µg, respectively).
Conclusion: The nanocrystal formulation of erythromycin presented in this study holds promise as an innovative approach to enhance the solubility, dissolution rate, and antibacterial activity of erythromycin for effective pulmonary administration.
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