Data associated to the study entitled:"Alterations of the nigrostriatal pathway in a 6-OHDA rat model of Parkinson's disease evaluated with multimodal MRI"
Creators
- 1. UPMC / INSERM UMR975, Brain and Spine Institute, Paris, France
- 2. Center for Neuroimaging Research, Brain and Spine Institute, Paris, France
Description
Parkinson’s disease is characterized by neurodegeneration of the dopaminergic neurons in the substantia nigra pars compacta. The 6-hydroxydopamine (6-OHDA) rat model has been used to study neurodegeneration in the nigro-striatal dopaminergic system. The goal of this study was to evaluate the reliability of diffusion MRI and resting-state functional MRI biomarkers in monitoring neurodegeneration in the 6-OHDA rat model assessed by quantitative histology.
We performed a unilateral injection of 6-OHDA in the striatum of Sprague Dawley rats to produce retrograde degeneration of the dopamine neurons in the substantia nigra pars compacta. We carried out a longitudinal study with a multi-modal approach combining structural and functional MRI together with quantitative histological validation to follow the effects of the lesion. Functional and structural connectivity were assessed in the brain of 6-OHDA rats and sham rats (NaCl injection) at 3 and 6 weeks post-lesioning using resting-state functional MRI and diffusion-weighted.
The shared datafile corresponds to the MRI biomarkers extracted from diffusion and functional acquisitions as well as from histological mesaurements within striatum and substantia nigria.
Files
data_study_6OHDA_MRI.csv
Files
(8.2 kB)
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