Published July 17, 2018
| Version v1
Dataset
Open
Co-crystal structures of USP5 Zf-UBD and weak binding compounds
Creators
- 1. Structural Genomics Consortium, University of Toronto
Description
Determination of crystallization conditions which allow growth of well-diffracting co-crystals of USP5 zinc finger ubiquitin binding domain (Zf-UBD) and compounds shown to bind weakly by 19F NMR and SPR assays & to solve the co-crystal structures to determine if electron density of ligands can be seen in the binding pocket of the protein domain.
Notes
Funding Acknowledgment: The SGC is a registered charity (number 1097737) that receives funds from AbbVie, Bayer Pharma AG, Boehringer Ingelheim, Canada Foundation for Innovation, Eshelman Institute for Innovation, Genome Canada through Ontario Genomics Institute [OGI-055], Innovative Medicines Initiative (EU/EFPIA) [ULTRA-DD grant no. 115766], Janssen, Merck KGaA, Darmstadt, Germany, MSD, Novartis Pharma AG, Ontario Ministry of Research, Innovation and Science (MRIS), Pfizer, São Paulo Research Foundation-FAPESP, Takeda, and Wellcome.
Files
20180717 USP5 cocrystal structures.pdf
Files
(20.6 MB)
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