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Compounds of interest identified by screening a focused library against USP5 Zf-UBD with a 19F NMR assay

Mann, Mandeep; Houliston, Scott; Harding, Rachel; Freitas, Renato; Franzoni, Ivan; Edwards, Aled; Arrowsmith, Cheryl; Schapira, Matthieu

Screening a set of commercial compounds selected from computational docking studies against USP5 zinc finger ubiquitin binding domain (Zf-UBD) using 19F NMR spectroscopy. You can find details of preliminary 19F NMR experiments here.

Funding Acknowledgment: The SGC is a registered charity (number 1097737) that receives funds from AbbVie, Bayer Pharma AG, Boehringer Ingelheim, Canada Foundation for Innovation, Eshelman Institute for Innovation, Genome Canada through Ontario Genomics Institute [OGI-055], Innovative Medicines Initiative (EU/EFPIA) [ULTRA-DD grant no. 115766], Janssen, Merck KGaA, Darmstadt, Germany, MSD, Novartis Pharma AG, Ontario Ministry of Research, Innovation and Science (MRIS), Pfizer, São Paulo Research Foundation-FAPESP, Takeda, and Wellcome.
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