Dataset Open Access

Compounds of interest identified by screening a focused library against USP5 Zf-UBD with a 19F NMR assay

Mann, Mandeep; Houliston, Scott; Harding, Rachel; Freitas, Renato; Franzoni, Ivan; Edwards, Aled; Arrowsmith, Cheryl; Schapira, Matthieu

Screening a set of commercial compounds selected from computational docking studies against USP5 zinc finger ubiquitin binding domain (Zf-UBD) using 19F NMR spectroscopy. You can find details of preliminary 19F NMR experiments here.

Funding Acknowledgment: The SGC is a registered charity (number 1097737) that receives funds from AbbVie, Bayer Pharma AG, Boehringer Ingelheim, Canada Foundation for Innovation, Eshelman Institute for Innovation, Genome Canada through Ontario Genomics Institute [OGI-055], Innovative Medicines Initiative (EU/EFPIA) [ULTRA-DD grant no. 115766], Janssen, Merck KGaA, Darmstadt, Germany, MSD, Novartis Pharma AG, Ontario Ministry of Research, Innovation and Science (MRIS), Pfizer, São Paulo Research Foundation-FAPESP, Takeda, and Wellcome.
Files (18.4 MB)
Name Size
20180605_19FNMR_cpd_screening.pdf
md5:961b49e1a00a5a751cf86ce72588d158
699.4 kB Download
20180605_USP5ZfUBD 19F NMR spectra.zip
md5:ad4a01d83905b8e77f4c57b3d65e9c93
17.3 MB Download
UPLCMS 19F NMR cpds.pdf
md5:8e6763cd7742e81348331b3c16164279
449.6 kB Download
220
125
views
downloads
All versions This version
Views 220222
Downloads 125125
Data volume 546.1 MB546.1 MB
Unique views 184186
Unique downloads 7474

Share

Cite as