Conference paper Open Access

A phantom feasibility study of acoustic enhanced drug perfusion in neurological tissue

Lewis, George K.; Olbricht, William

Abstract--To test the feasibility of using 1.1MHz focused ultrasound to increase the diffusion of drug through neurological tissue, tissue mimicking agar phantoms and a water soluble dye mimicking drug were exposed to 1.1MHz ultrasonic sound fields for 1 to 4 minutes in duration. Histology was then performed on the phantoms to assess the effect of ultrasound on the perfusion of drug. Mathematical analysis was used to quantify the extent of perfusion of dye and parametrically fit the experimental data to the theoretical diffusion equation. Results show a substantial increase in drug perfusion and not diffusion like behavior for the sonicated phantoms.

Files (805.3 kB)
Name Size
article.pdf
md5:53de4f98bee586fbf9e11de0fd0c4b48
805.3 kB Download
43
81
views
downloads
Views 43
Downloads 81
Data volume 65.2 MB
Unique views 43
Unique downloads 81

Share

Cite as