Published August 1, 2002 | Version v1
Journal article Open

Live or let die: the cell's response to p53.

Description

Compared with many normal tissues, cancer cells are highly sensitized to apoptotic signals, and survive only because they have acquired lesions - such as loss of p53 - that prevent or impede cell death. We are now beginning to understand the complex mechanisms that regulate whether or not a cell dies in response to p53 - insights that will ultimately contribute to the development of therapeutic strategies to repair the apoptotic p53 response in cancers.

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