EVIDENCE OF DNA DAMAGE IN SUBJECTS WITH SEVERE HYPOTHYROIDISM AND DYSLIPIDEMIA.

Thyroid diseases are one of the commonly occurring endocrine disorders worldwide. About 42 million people in India suffer from varied thyroid disorders. Thyroid hormones significantly affect lipoprotein metabolism as well as some CVD risk factors, thus influencing the overall CVD risk. The goal of the present study was to evaluate the evidence of DNA damage in subjects with severe hypothyroidism and dyslipidemia. The present study consists of 50 study subjects suffering from hypothyroidism along with dyslipidemia and 20 healthy control subjects. The extent of DNA damage was quantified by Cytokinesis-Block Micronuclei (CBMN) assay. Detailed demographic, clinical and lifestyle characteristics were compared with subjects. The micronuclei frequency was significantly elevated in study subjects as compared with that of control subjects. Various risk factors such as demographic, biochemical, hormonal and lifestyle characters were showed increased micronuclei, which leads to CVD. Thyroid disorders should be recognized and treated. Cardiovascular risk factors can be reduced by optimal metabolic control and lifestyle modification.