Changes in activity of some indicators of pro-oxidant and antioxidant systems in guinea pigs' lungs in experimental allergic alveolitis and their correction with thiotriazolin

Baida Mariana Ljubomurivna, Sadljak Oksana Volodumurivna, Reheda Stepan Mykhailovuch. Changes in activity of some indicators of pro-oxidant and antioxidant systems in guinea pigs’ lungs in experimental allergic alveolitis and their correction with thiotriazolin. Journal of Education, Health and Sport. 2017;7(12):612-618. eISSN 2391-8306.

DOI http://dx.doi.org/10.5281/zenodo.1162832

http://ojs.ukw.edu.pl/index.php/johs/article/view/5233

The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26.01.2017).

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

© The Authors 2017;

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This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial

use, distribution and reproduction in any medium, provided the work is properly cited.

The authors declare that there is no conflict of interests regarding the publication of this paper.

Received: 01.12.2017. Revised: 15.12.2017. Accepted: 25.12.2017.

CHANGES IN ACTIVITY OF SOME INDICATORS OF PRO-OXIDANT AND ANTIOXIDANT SYSTEMS in guinea pigs’ lungs in experimental allergic alveolitis AND THEIR CORRECTION WITH THIOTRIAZOLIN

Mariana Ljubomurivna Baida1, Oksana Volodumurivna Sadljak2,

Stepan Mykhailovuch Reheda3

Danylo Halytsky Lviv National Medical University

1Department of pathological physiology, PhD, assistant professor

²Department of pathological physiology, PhD, associate professor

3Department of pathological physiology, postgraduate student

Lviv, Ukraine

Abstract

These changes correlate with the development of oxidative stress in animals over the entire duration of the experiment, which manifested by an increase in the content of the lipoperoxidation products (LPO) - conjugated diene level and malonic dialdehide) in the lungs in comparison with control group. Decreasing of the antioxidant activity (a significant reduction of peroxidase and ceruloplazmin level) in the lung`s tissure of guinea pigs has been reported. Correction of these shifts with the antioxidant drug thiotriazolin inhibits accumulation of LPO products and increases antioxidant defense. The experimental data most probably indicate a pronounced effect of thiotriazolin on the realization of the antiinflammatory and antioxidant effects and allows a suggestion about the antiradical mechanism of this drugs.

Key words: experimental allergic alveolitis, peroxide lipid oxidation, antioxidant system,thiotriazolin.