Clinical Evaluation of Nitrofurantoin in Patients of Acute Lower Urinary Tract Infection

Objective:  The Urinary tract is one of the most common source for life threatening infection.  A broad range of organisms may be isolated. Various antibiotics are used for the treatment but rising resistance among pathogenic organisms is one major concern in choosing effective treatment option. The main objective of the study was to check the efficacy and safety of nitrofurantoin (100 mg BD dose) for five days in cases of acute lower UTI. Material and Methods Study design: open label, single arm study.  Study population: Seventy patients presenting with clinical symptoms of urinary tract infection were selected which were further confirmed by urine culture in the microbiology department.   Protocol: Urine culture and sensitivity testing for nitrofurantoin was done. After confirmation of the causative organism and sensitivity testing patients were prescribed nitrofurantoin (100 mg BD) for five days and were told to revisit the OPD on 7th day. Urine culture was repeated to see the bacterial eradication rate. Results: Sensitivity reported to nitrofurantoin is 84.3%. Among all the pathogenic organism’s highest sensitivity was shown by Proteus (87.5%), followed by E. coli (84.7%), Staphylococcus aureus (83.3%), Klebsiella (70%). The bacterial eradication rate is 91.5%.