FORMULATION AND EVALUATION OF ANTIDANDRUFF HAIR GEL.

At present, there are number of antifungal agents use topical applications like clotrimazole, griseofulvin, itraconazole, fluconazole etc. Clotrimazolewas used as a model drug. Clotrimazole is an imidazole derivative with a broad spectrum anti mycotic activity. It acts by inhibiting biosynthesis of ergosterol, an important component of fungal cell membranes. It is widely used for the treatment of local candidacies, vaginal yeast infections; topical applications include fungal infections such as ring worm, athlete?s foot and jock itch. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane. The major drawback of this drug is its insolubility in water. The techniques generally employed to enhance the solubility of poorly water soluble drugs are, use of surface active agent, hydrates and solvates ,polymorphism, complexation, solid dispersion. Among this Solid dispersion is a unique technique used to increase solubility, dissolution and bioavailability of poorly water-soluble drugs. Conventional method for preparing solid dispersion includes solvent wetting method, physical mixture, complex formations, and solvent evaporation techniques. Creams, gels, ointments and pastes are some of the topical semisolids in use for many decades. The extensive studies on release properties have revealed that the active ingredients in gel based formulations are better percutaneously absorbed than cream or ointment bases