A REVIEW ON FLURO-SUBSTITUED BENZOTHIOZOLES: A NEW PROFILE OF BIOLOGICAL ACTIVITIES

Benzothiazoles are an important class of bioactive & industrially important organic compounds recently; heterocyclic compounds analogues and their derivatives have attracted strong interest in medicinal chemistry due to their biological and pharmacological properties. Heterocyclic compounds analogues and their derivatives have attracted strong interest due to their biological and Pharmacological properties. Benzothiazoles are bicyclic ring system. A number of 2‐Aminobenzothiazoles have been studied as central muscle relaxants and found to interfere with glutamate neurotransmission in biochemical, electrophysiological and behavioural experiments Benzothiazoles derivatives have been studied and found to have various chemical reactivity and biological activity. Benzothiazole ring made from thiazole ring fused with benzene ring. Thiazole ring is a five‐member ring consists of one nitrogen and one sulphuratom in the ring. The benzothiazole nucleus containing compounds involved in research aimed at evaluating new products that possess biological activities, such as antimicrobial, anticancer, antifungal, anthelmintic, anti-diabetic, and anticancer agents. It is well known that the introduction of fluorine atom into an organic molecule causes dramatic changes in its biological profile, mainly due to high electro negativity of fluorine, the strong carbon-fluorine bond and increased solubility in lipids. These compounds are reported for their antimicrobial and anti-inflammatory, anti tubercular, anthelmintic, antifungal, anti-cancer, anti convulsant activities. Various fluoro substituted benzothiazoles with substituted derivatives they are synthesized by various methods Keywords: Benzothiazole, Anti-inflammatory, Antimicrobial, Anthelmintic, Anti convulsant