Cell-free DNA Fragmentomics and Second Malignant Neoplasm Risk in Patients with PTEN Hamartoma Tumor Syndrome

Supplementary dataset for manuscript

Affiliations:

¹Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA

²Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH 44195, USA

³Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Cleveland Clinic, Cleveland, OH 44195, USA

⁴Center for Personalized Genetic Healthcare, Medical Specialties Institute, Cleveland Clinic, Cleveland, OH 44195, USA

⁵Center for Immunotherapy and Precision Immuno-oncology, Cleveland Clinic, Cleveland, OH 44195, USA

⁶Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH 44195, USA

⁷Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA

⁸Germline High Risk Cancer Focus Group, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA

Correspondence:

Charis Eng, MD, PhD (https://orcid.org/0000-0002-3693-5145)

Cleveland Clinic Genomic Medicine Institute

9500 Euclid Avenue NE50, Cleveland, OH 44195, USA

Tel: +1 (216) 444-3440, Fax: +1 (216) 636-0009, E-mail: engc@ccf.org