Thrombotic Microangiopathic Haemolytic Anaemia: A Pathologic Abnormality Associated with Diverse Clinical Syndromes

A pathological process of microvascular thrombosis, microangiopathic hemolytic anemia and thrombocytopenia, with ischemia and infraction, affecting particularly kidney and brain is Thrombotic microangiopathy  (TMA). Disseminated intravascular coagulation (DIC) is caused by severe infectious disease and systemic inflammatory syndrome (SIRS). Thrombotic microangiopathy  (TMA) a rare but devastating disease, also known as microangiopathic hemolytic anemia (MAHA) in combination with thrombocytopenia and signs of organ damage. These pathological features are included in different clinical syndromes, such as hemolytic uremic syndrome (HUS), thrombotic thrombocytopenic purpura (TTP), and HELLP syndrome in pregnancy. Now comes to secondary TMA which canbe triggered by many factors such as various drug, bone marrow transplantation, infections and malignant diseases.