Published March 28, 2012
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Release Behavior of Biodegradable and Nonbiodegradable Polymeric Microparticles Loaded with Nimesulide
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Description
This presentation narrates the comparative analysis of
the dissolution data nimesulide microparticles prepared with
ethylcellulose, hydroxypropyl methylcellulose, chitosan and
Poly(D,L-lactide-co-glycolide) as polymers. The analysis of release
profiles showed that the variations noted in the release behavior of
nimesulide from various microparticulate formulations are due to the
nature of used polymer. In addition, maximum retardation in the
nimesulide release was observed with HPMC (floating particles).
Thus HPMC miacroparticles may be preferably employed for
sustained release dosage form development.
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References
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- S. A. Khan, M. Ahmad, G. Murtaza, M. N. Aamir, F. Rasool, M. Akhtar, "Study of nimesulide release from ethylcellulose microparticles and drug-polymer compatibility analysis," Latin American Journal of Pharmacy, vol. 29, no. 4, pp. 554-561, March 2010.
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- S. A. Khan, M. Ahmad, M. N. Aamir, F. Rasool, G. Murtaza, "Design of Nimesulide-Chitosan Microparticles by pH Change Coacervation," Latin American Journal of Pharmacy, vol. 30, no. 7, pp. 1160-1266, June 2011.