Published June 22, 2008 | Version 14119
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Protein Secondary Structure Prediction

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Protein structure determination and prediction has been a focal research subject in the field of bioinformatics due to the importance of protein structure in understanding the biological and chemical activities of organisms. The experimental methods used by biotechnologists to determine the structures of proteins demand sophisticated equipment and time. A host of computational methods are developed to predict the location of secondary structure elements in proteins for complementing or creating insights into experimental results. However, prediction accuracies of these methods rarely exceed 70%.

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References

  • Cuff, J. A. and Barton, G.J. "Evaluation and improvement of multiple sequence methods for protein secondary structure prediction. Proteins, 34, 1999, pp. 508-519.
  • Cuff, J.A. and Barton G.J. "Application of multiple sequence alignment profiles to improve protein secondary structure prediction" Proteins, 40, 2000, pp. 502-511.
  • Jones, D.T. "Protein secondary structure prediction based on positionspecific scoring matrices" Journal of Molecular Biology, 292, 1999, pp. 195 -202.
  • Kabsch, W. and Sander, C. "Dictionary of protein secondary structure: Pattern recognition of hydrogen-bonded and geometrical features" Biopolymers, 22, 1983, pp. 2577-2637.
  • Kloczkowski, A., Ting, K.L., Jernigan, R.L. and Garnier, J. "Combining the GORV algorithm with evolutionary information for protein secondary structure prediction from amino acid sequence" Proteins, 49, 2002, pp. 154-166.
  • Krane, D. and Raymer, M. (2003), "Fundamental Concepts of Bioinformatics", Pearson Education, New Delhi, pp.1-314.
  • Moult, J., Hubbard, T., Bryant, S.H., Fidelis, K. and Pedersen, J.T. "Critical assesment of methods of protein structure prediction (CASP): round II". Proteins, S1, 1992, pp. 2-6.
  • Rost, B. and Sander, C. (1993) "Prediction of protein secondary structure at better than 70% accuracy" Journal of Molecular Biology, 232, pp. 584-599.
  • Sander, C. and Schneider, R. "Database of homology-derived structures and the structural meaning of sequence alignment" Proteins, 9, 1991, 56- 68.