Evaluation of the Possible Effect of Gender, Age and Duration of Diabetes on the Serum Zinc Levels of Diabetic Patients in Murzuk Area-Libya
Description
The aim of this study was to demonstrate the possible effect of some variables such as age, gender, blood sugar level, and duration of diabetes on the serum level of zinc in diabetic individuals from Murzuk area. Serum zinc (Zn), Fasting blood sugar (FBS), hemoglobin HbA1c (HbA1c) were evaluated in 46 type I diabetic subjects (group 1), 48 type II diabetic subjects (group 2) and 43 healthy individuals (control) of both genders aged (30-81) years. Data showed that both diabetic groups have significantly higher (P<0.05) serum levels of Zn, FBS and HbA1c compared with controls. No significant (p>0.05) differences in serum Zn levels were observed between Males and Females. Serum Zn levels were non-significantly decreased with increasing age. In type II diabetic subjects, serum Zn levels were non-significantly decreased with increasing duration of disease whereas those in type I were non-significantly increased.
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References
- WHO, www.who.int/features, 2010.
- D. B. Chiranjib and K. P. Kumar, "A potential medical importance of zinc in human health and chronic disease," Int. J. Pharm. Biomed. Sci., vol. 1,no. 1, pp.05-11, 2010.
- A. B. Chausmer, "Zinc, insulin and diabetes," J. Am. Collg. Nutr., vol. 17, no. 2, pp. 109-115, 1998.
- A. El-Yazigi, N. Hannan, and D. A. Raines, "Effect of diabetic state and related disorders on the urinary excretion of magnesium and zinc in patients," Diab. Res., vol. 22, no. 2, pp. 67-75, 1993.
- I. Nourmohammadi, I. Kocheki-shalmani, and M. Shaabani," Zinc, copper, chromium, manganese and magnesium levels in serum and hair of insulin-dependent diabetics," Arch. Irn. Med., vol. 3, pp. 129-29, 2000.
- A. Syogren, C. Floren, and A. Nilsson,"Magnesium, potassium, and zinc deficiency in subjects with type II diabetes mellitus," Acta. Med. Scand., vol. 224, pp. 461-465, 1988.
- J. D. Kruse-Jerres, M. Rukgauer,"Trace elements in diabetes mellitus. Peculiarities and clinical validity of determinations in blood cells," J. Trace Elements Med. Biol., vol. 14, no. 1, pp. 21-27, 2000.
- A. H. Zargar, N. A. Shah, and S.R. Massodi, "Copper, zinc, and magnesium levels in non-insulin dependent diabetes mellitus," Postgard. Med. J., vol. 74, pp.665-668, 1998.
- M. Estakhari, A. Djazayery, M. R. Eshraghian, R. Majdzadeh, M. Jalali, et al.,"Serum zinc levels in Children and adolescents with type I diabetes mellitus," Iranian J. Publ. Health, vol. 40, no. 4, pp. 83-88, 2011. [10] R. D. Rohn, P. Pleban, and L. L. Jenkins, "Magnesium, zink and copper in plasma and blood cellular components in children with IDDM," Clin. Chim. Acta, vol. 215, no. 1, pp. 21-28, 1993. [11] D. Barham and P. Trinder, "An improved colour reagent for the determination of blood glucose by the oxidase system," Analyst, vol. 97, pp. 142 - 145, 1972. [12] K. Spencer, "Analytical reviews in clinical biochemistry. The estimation of creatinine," Ann. Clin. Biochem.,vol. 23, pp. 1-25,1986. [13] M. P. Veniamin and C. Vakirtz-lemonias, "Chemical basis of the carbamido diacetyl micro method for estimation of urea, citrulline and carbamyl derivatives," Clin. Chem., vol. 16, pp. 3-6, 1970. [14] American Diabetes Association (ADA), "Executive summary; Standards of medical care in diabetes," Diabetic Care, vol. 32, pp. S6-S12, 2009. [15] K. I. Akhuemokhan, A. Eregie, and O. A. Fasanmade, "Trace mineral status and glycaemic control in Nigerians with type 2 diabetes," Afri. J. Med., pp. 20-22, July 2010. [16] A. C. Nsonwu, C. A. Usoro, M. H. Etukudo, and I. N. Usoro, "Influence of age, gender and duration of diabetes on serum and urine levels of zinc, magnesium, selenium and chromium in type 2 diabetics in Calabar, Nigeria," Turk. J. Bioch., vol. 31, no. 3, pp. 107-114, 2006.