SYNTHESIS AND ANALYSIS OF COPPER(II) ION COORDINATION COMPOUND WITH KETOPROFEN AND CARBAMIDE

Nowadays, great amount of interest in the development of methods for the synthesis of metallocomplex compounds of biologically active compounds available in the world with 3d metals and in determining their physicochemical properties is steadily increasing. These compounds are actual for their use as antibiotics and painkillers in pharmaceutics, as biologically active substances in medicine, and as antibacterial active substances that inhibit the growth of bacteria for microorganism cells [1]. The synthesis of the complex combination of 2-(3-benzoylphenyl) propionic acid (Ketoprofen) with Cu²⁺ from saturated monocarboxylic acid derivatives was studied. Factors affecting the synthesis of CuC₃₄H₃₄N₄O₈ complex compound under room conditions were shown. In particular, the dependence of the yield of the reaction product on time, the effect of temperature, and the dependence on concentration were studied in practice. Physico-chemical research of the synthesized complex compound was studied using IR-Fourier-spectroscopy, elemental analysis, mass spectrometry, TG-DSK and X-ray structural analysis methods, its chemical structure was determined, and it was proved that this new complex compound is thermally and chemically stable. [2].