Published December 7, 2017
| Version v1
Dataset
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Raw diffraction images of human orexin 2 receptor bound to the subtype-selective antagonist EMPA
Creators
- 1. Kyoto University
- 2. RIKEN SPring-8 Center
- 3. The University of Texas Southwestern Medical Center
Description
Human orexin 2 receptor (OX2R) is a member of G protein-coupled receptors (GPCR). OX2R plays important roles in modulating feeding behavior and regulating the sleep-wake cycle.
805 small-wedge (1-6°/crystal) datasets collected from loop-harvested microcrystals using MX225HS CCD detector at a wavelength of 1 Å on BL32XU, SPring-8. The crystals belonged to space group C2 with unit cell parameters a=94.1, b=75.5, c=95.9 Å, β=111.4°.
631 datasets were merged at 1.96 Å resolution in the published result (Suno et al. Structure 2017; PDB code: 5WQC) using KAMO; see https://github.com/keitaroyam/yamtbx/wiki/Processing-OX2R-data-(5WQC)
Note
- Most frames have lipid rings.
- One dataset (not included in the published result) was lost for some reason (so 804 datasets are available).
Files
Files
(19.6 GB)
Additional details
Related works
- Cites
- 10.2210/pdb5wqc/pdb (DOI)
- Is cited by
- 10.1016/j.str.2017.11.005 (DOI)