ON THE ISSUE OF METABOLIC DISORDERS AND THEIR CORRECTION IN CHRONIC HEPATITIS

The aim of this study was to examine the state of the antioxidant system in patients with HCV and correction of pathogenetic therapy, taking into account changes in glutathione-dependent enzymes. Materials and methods. The paper presents the results of a survey 83 patients with chronic hepatitis C between the ages of 19 to 55 years, and 20 healthy people with a lack of hepatitis markers. Status of antioxidant protection was measured in terms of the activity of glutathione and glutathione-dependent enzymes: glutathione peroxidase (GP), glutathione reductase (GR), glutathione transferase (GT). Results. The results showed that the examined patients with HCV showed a significant suppression of the activity of glutathione-dependent enzymes and the decrease in total glutathione levels. For the correction of the system used in the preparation of glutathione "Glution" in doses ranging from 600 to 1200 mg per day for 10 days. Conclusion. Research has shown that patients with HCV decreased activity of antioxidant protection. Determine the feasibility of incorporating the complex pathogenetic therapy "Glution" the drug, taking into account the individual levels of glutathione deficiency.