FORMULATION AND EVALUATION OF LOSARTAN POTASSIUM MICROSPHERES BY SOLVENT EVAPORATION METHOD

Losartan Potassium loaded microspheres were prepared by solvent evaporation method with combination of hydroxy propyl methyl cellulose and Carbopol polymers in various proportions. A total of nine formulations were prepared. The particle size of all the formulations were ranged between 112±0.02 and 183±0.01μm. The entrapment efficiency was ranged between 68.38±0.01 and 93.16±0.01 All formulations were evaluated for further studies like micromeretic properties, swelling index and in-vitro release profile. It was confirmed with the results of micromeretic property that all the selected formulations showed good flow property. A microsphere was found to be sustained over 12 hours. Hence, it can be concluded that the Formulation prepared by solvent evaporation method, has potential to deliver LosartanPotassium in a controlled manner in a regular fashion over extended period of time in Comparison to all other formulations and can be adopted for a successful oral delivery of Losartan potassium for safe management of hypertension. The Losartan potassium microspheres were prepared successfully by solvent evaporation technique using combination of novel polymers and the in vitro release studies have shown that better release profile with combination of polymers especially with increase in Carbopol concentration.