MECHANISMS OF ACTION OF GLYCYRRETIC ACID AND ITS DERIVATIVES ON MITOCHONDRIAL MEMBRANES

The article examines the effect of new synthetic derivatives of glycyrrhetic acid (GrA) on the functional parameters of mitochondria (Mx), as well as the parameters of the CsA-sensitive pore of Mx membranes. As a result of the studies, it was shown for the first time that the derivatives of GrK are 2-(N-cytisine)-ethyl-3-0-acetyl-18bH-glycyrrhetate (cytisine-ethyl-GC), 2-(N-cytisine)-isopropyl-3-0-acetyl-18bH-glycyrrhetate (cytisine-isopropyl-GC) and N-(2-pyridyl)-3-0-acetyl-11-ketoolean-12-ene-30-amide (2-pyridyl-GC -amide) inhibit the activity of the CsA-sensitive pore and have a protective effect on Mx membranes. At the same time, the damaging effect of Ca2+ ions and the lipid peroxidation process is reduced. Other derivatives of GrK- N-(4-pyridyl)-3-0-acetyl-11-ketooleane-12-en-30-amide (4-pyridyl-GC-amide) and Са2+(N-morpholine)-ethyl-3 -O-acetyl-18bH-glycyrrhetate (morpholine-GC) uncouples OF, enhances the damaging effect of CsA-sensitive pore inducers on membranes, increasing their permeability to cations.