FEATURES OF DETERMINATION OF PROGNOSTIC AND DIAGNICALLY SIGNIFICANT MARKERS IN THE BLOOD OF PATIENTS WITH PULMONARY TUBERCULOSIS

Throughout the world, the epidemiological situation with regard to tuberculosis remains difficult. Purpose of the study: to study the immunobiological properties of the organism in newly diagnosed patients with pulmonary tuberculosis. We conducted a study on the presence of prognostic and diagnostically significant markers in the blood serum of 30 patients with a verified diagnosis. A comparative group contains 15 practically healthy persons. All patients underwent general clinical, bacterioscopic examination, chest X-ray. It is determined the concentration of cytokines - TNF- α and CRP, VGF.

Conclusions: A moderate increase in the level of CRP allows early detection of the course of the pathological process and as certain the formation of a systemic inflammatory response to activate phagocytosis. Correlation of a decrease in the concentration of TNF- α in the blood serum in patients with recurrent disease secondary to an increase in the level of VEGF in the same patients.