Histopathological Examination of Appendicectomy Specimens: Common Detected Pathologies and Negative Appendectomy Rate in Patients Undergoing Appendicectomy

ABSTRACT
Acute appendicitis is one of the commonest surgical emergency worldwide, appendectomy or appendicectomy among the commonest surgical procedures that performed on daily practice. Histopathology is the gold standard for diagnosis of gold standard of all examined specimens after appendectomies. The Negative appendectomy result from excision of normal appendix. Intra-operative gross examination and pre-operative imaging and other investigations still have some diagnostic limitations compared to histopathology. The objective of our study is to assess the results of histopathological examination of appendicectomy specimens and the common detected pathologies and estimate the negative appendectomy rates in patients undergoing appendicectomy. We included 117 specimens of patients after appendectomies. Standard laboratory histopathological protocols and procedures were followed  in collection and processing of these specimens. Results of our study showed that most patients were at young age (11 – 30) years with predominance of males in a male to female ratio of almost 1.4 to one. Negative appendectomy rate (NAR) was 17.1% and was comparable to the accepted global ranges.  In conclusion, conducting histological analysis of the appendix specimens provides valuable clinical insights in conjunction with operational findings, a significant higher prevalence of appendicitis among individuals younger than 30 years. Females , older age patients and those with high preoperative WBC count exhibited a higher negative appendectomy rates. Hence, in order to prevent the oversight of any clinically significant and manageable conditions, it is imperative to incorporate a systematic histological investigation into the routine analysis of all appendicectomy specimens.