Published November 3, 2023
| Version v3
Dataset
Open
distinct mesenchymal cell states mediate prostate cancer progression
Creators
- Pakula, Hubert1
- Omar, Mohamed1
- Carelli, Ryan1
- Pederzoli, Filippo1
- Fanelli, Giuseppe Nicolò2
- Pannellini, Tania1
- Emmenis, Lucie Van1
- Rodrigues, Silvia1
- Fidalgo-Ribeiro, Caroline1
- Nuzzo, Pier V.1
- Brady, Nicholas J.1
- Jere, Madhavi1
- Unkenholz, Caitlin1
- Mohammad, Mohammad1
- Khani, Francesca1
- de Almeida, Francisca Nunes3
- Rickman, David S.1
- Barbieri, Christopher E.4
- Robinson, Brian D.1
- Marchionni, Luigi1
- Loda, Massimo1
- 1. Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY 10021, USA
- 2. Department of Laboratory Medicine, Pisa University Hospital, Division of Pathology, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa 56126, Italy
- 3. Department of Molecular Pharmacology and Therapeutics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.
- 4. Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, Belfer Research Building, 413 East 69th Street, New York, NY 10021, USA
Description
These are the count matrices (in .h5ad format) used to produce the results and figures in the paper entitled "distinct mesenchymal cell states mediate prostate cancer progression".
- adata_mouse.h5ad: the normalized count matrix and cell annotations for the mesenchymal prostate data from all mouse models.
- adata_mouse_myo.h5ad: the normalized count matrix for the myofibroblasts and pericytes (both are c0).
- scenic_mesenchyme_auc.csv: the auc matrix of the regulons activity in the different cells and clusters in the mouse mesenchymal data.
- scenic_mesenchyme_binary.csv: the binary matrix of regulons activity in the mouse mesenchymal data.
- adata_human.h5ad: the normalized count matrix and cell annotations for the mesenchymal human primary prostate cancer data.
- adata_human_boneMet_stroma.h5ad: the normalized count matrix and cell annotation for the bone metastasis data derived from Kfoury et al.
- visium_PRN.h5ad: the normalized count matrix and cell annotation for the Visium spatial transcriptomics data of the PRN mouse model.
- visium_WT.h5ad: the normalized count matrix and cell annotation for the Visium spatial transcriptomics data of the WT (PRN-WT) mouse model.
- natHistory_expression: the normalized expression matrix for the natural history cohort.
- natHistory_label: the metastasis indicators for the natural history cohort.
Files
metadata_mouse.csv
Files
(2.1 GB)
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