Published August 22, 2025 | Version v1
Dataset Open

Additional Supplement Data of the manuscript "Genome-Wide Association Study of Asthma Exacerbations in the Spanish Population"

Creators

  • 1. ROR icon Universidad de La Laguna
  • 2. ROR icon Hospital Universitario Nuestra Señora de Candelaria
  • 3. Hospital General de la Palma
  • 4. ROR icon Hospital Universitario de Canarias
  • 5. University of the Basque Country (EHU/UPV)
  • 6. Donostia University Hospital
  • 7. ROR icon Osakidetza
  • 8. Division of Pediatric Respiratory Medicine, Hospital Universitario Donostia, San Sebastián, Spain.
  • 9. Respiratory Medicine, Hospital Dr. José Molina Orosa, Arrecife, Las Palmas, Spain.
  • 10. ROR icon Servicio Canario de la Salud
  • 11. CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain; Departamento de Medicina Respiratoria, Hospital Vall d'Hebron, Barcelona, Spain.
  • 12. ROR icon Universidade de Santiago de Compostela
  • 13. ROR icon Complejo Hospitalario Universitario de Santiago
  • 14. ROR icon Hospital Universitari Germans Trias i Pujol
  • 15. IDIBAPS - Hospital Clínic
  • 16. ROR icon Complejo Hospitalario de Navarra
  • 17. ROR icon Hospital Universitario La Paz
  • 18. Universidad Autónoma de Madrid Facultad de Medicina
  • 19. FUNDACION JIMENEZ DIAZ
  • 20. CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain; Research Unit at Hospital Universitario Dr. Negrín, Fundación Canaria Instituto de Investigación Sanitaria de Canarias, Las Palmas, Spain; Faculty of Health Sciences, Universidad del Atlántico Medio, Tafira Baja, Las Palmas, Spain; Li Ka Shing Knowledge Institute at St Michael's Hospital, Toronto, Canada.

Description

For this manuscript we conducted a meta-analysis from genome-wide association study of asthma exacerbations in 345 adults from the Genomics and Metagenomics of Asthma Severity (GEMAS), 369 from Characterizing Alpha-1-Antitrypsin Deficiency in patients with pulmonary diseases (CAATDPUL), and 138 from MEchanisms involved in the Genesis and evolution of Asthma (MEGA) studies as discovery.

Summary statistics output is organized in the following columns:

  • RSID: Variant ID based on chromosome:position:effect allele:rsID
  • STUDY: number of studies or subsets were is present the probe
  • BETA_meta:  coefficient estimate
  • SEBETA_meta:  standard error
  • PVALUE_meta: raw p-value 
  • PVALUE_Q: p-value of Cochran’s Q
  • Model: FE (fixed effect) or RE2 (random effect)
  • PVALUE_meta_adj: adjusted p-value by false discovery rate
  • BP: Genomic positions are indicated in GRCh38 Genome Assembly
  • CHR: Chromosome

Files

GEMAS_adults_Exacerbations_age-sex-pc12.txt

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Additional details

Related works

Is supplement to
Dataset: 10.1016/j.arbres.2025.03.012 (DOI)

References

  • Martin-Gonzalez, E., Perez-Garcia, J., Martin-Almeida, M., Hernández-Pérez, J. M., González-Pérez, R., Sardón, O., Pérez-Pérez, J. A., González-Carracedo, M. A., Poza-Guedes, P., Sánchez-Machín, I., Mederos-Luis, E., Corcuera, P., López-Fernández, L., Román-Bernal, B., González-García, L. M., Cruz, M. J., González-Barcala, F. J., Martínez-Rivera, C., Mullol, J., Muñoz, X., … Pino-Yanes, M. (2025). Genome-wide Association Study of Asthma Exacerbations in the Spanish Population. Archivos de bronconeumologia, 61(8), 490–494. https://doi.org/10.1016/j.arbres.2025.03.012