Published August 18, 2025 | Version v1
Dataset Open

Additional Supplement Data of the manuscript "Multi-Ancestry Epigenome-Wide Association Study of Asthma Exacerbations""

Creators

  • 1. ROR icon Universidad de La Laguna
  • 2. ROR icon University of California, San Francisco
  • 3. ROR icon Hospital Universitario de Canarias
  • 4. ROR icon Hospital Universitario Nuestra Señora de Candelaria
  • 5. Hospital General de la Palma
  • 6. University of the Basque Country (EHU/UPV)
  • 7. Donostia University Hospital
  • 8. ROR icon Osakidetza
  • 9. ROR icon Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
  • 10. ROR icon Hospital Universitario de Gran Canaria Doctor Negrín
  • 11. ROR icon Universidad del Atlántico Medio
  • 12. ROR icon St. Michael's Hospital
  • 13. Centro de Neumología Pediátrica, San Juan, Puerto Rico, USA.

Description

For this manuscript we conducted a meta-analysis from epigenome-wide association study of asthma exacerbations in 599 Latino and 394 African Americans as discovery ("2_EWAS_MetaResults_Multiancestry_GALA_SAGE__bacon_exacerbations_mval_lineal_age_sex_pcs_rcs_filtered.txt"). In addition, we also performed a multi-ancestry meta-analysis including GEMAS study, which included 312 Canary Islanders and 94 Basques ("2_EWAS_MetaResults_Multiancestry_GALA_SAGE_CAN_PV_bacon_exacerbations_mval_lineal_age_sex_pcs_rcs_filtered.txt"). 

Summary statistics output is organized in the following columns:

  • RSID: Probe ID
  • STUDY: number of studies or subsets were is present the probe
  • BETA_meta:  coefficient estimate
  • SEBETA_meta:  standard error
  • PVALUE_meta: raw p-value 
  • PVALUE_Q: p-value of Cochran’s Q
  • Model: FE (fixed effect) or RE2 (random effect)
  • PVALUE_meta_adj: adjusted p-value by false discovery rate

Files

2_EWAS_MetaResults_Multiancestry_GALA_SAGE__bacon_exacerbations_mval_lineal_age_sex_pcs_rcs_filtered.txt

Files (108.3 MB)

Additional details

Related works

Is supplement to
Dataset: 10.1111/all.70016 (DOI)

References

  • Martin-Gonzalez, E., Perez-Garcia, J., Martin-Almeida, M., Witonsky, J., Eng, C., Huntsman, S., Hu, D., Lorenzo-Diaz, F., González-Pérez, R., Hernández-Pérez, J. M., Poza-Guedes, P., Sardón-Prado, O., Sánchez-Machín, I., Mederos-Luis, E., Corcuera-Elosegui, P., Villar, J., Rodriguez-Santana, J., Ziv, E., Burchard, E. G., & Pino-Yanes, M. (2025). Multi-Ancestry Epigenome-Wide Association Study of Asthma Exacerbations. Allergy, 10.1111/all.70016. Advance online publication. https://doi.org/10.1111/all.70016