Published March 30, 2024 | Version v1
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Heme-based water aquareceptors

  • 1. Adam Mickiewicz University

Description

How cells sense water is a fundamental question in biology and for the evolution of life. The mechanisms underlying hygrosensation in numerous organisms and animals have been experimentally demonstrated. However, hygrosensation has mainly been investigated only in specialized sensory cells (hygroreceptors) that sense extracellular humidity. Even in single-celled microorganisms osmosensors are not sensing water molecule per se. In my opinion, cells must have the capability to sense water molecule per se via protein-based sensors or receptors (or aquareceptors) that would have enabled them to migrate and survive in water-scarce regions or conditions (via osmoadaptation or etc.,) and evolve into multicellular organisms. And, just as gas (solute)-sensing gasoreceptor functions in almost every cell, water-sensing aquareceptors must also function in almost every cell. Due to the potential capability of water molecules to regulate/antagonize the gas-binding sites in the heme moiety-containing sensor domains of gasoreceptors, I propose that some heme-based gas-sensing gasoreceptors may have a parallel role as water-sensing protein aquareceptors. And I wonder if hemoglobin can also be considered an putative aquareceptor. 

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Dates

Submitted
2024-03-30
Preprint