Mult-trait analysis of GWAS - Perceived youtfulness - UKBB

This is a cross-trait genome-wide association meta-analysis of perceived youthfulness in the UK Biobank (UKBB) split by sex. The analysis was performed using Multi-trait Analysis of GWAS (MTAG) software (DOI: 10.1038/s41588-017-0009-4). Traits were included in the analysis if they had a geentic correlation greater than 10% and with a P value < 2.3e-5. For full details see published manuscript.

Females - UKBB perceived facial aging; Yengo et al., 2018, BMI GWAS (DOI: 10.1093/hmg/ddy271); UKBB Vitamin E supplement use; UKBB Vitamin C supplement use; UKBB Zinc supplement use; UKBB age at first period; UKBB contraceptive pill use.

Males - UKBB perceived facial aging; Yengo et al., 2018, BMI GWAS (DOI: 10.1093/hmg/ddy271); Liu et al., 2019 Cigarettes per day (doi: 10.1038/s41588-018-0307-5); UKBB smoking status; UKBB male-pattern baldness four point scale; UKBB Diabetes status; UKBB Hypertension status; UKBB Age at first facial hair; 

Combined sex - UKBB perceived facial aging; Yengo et al., 2018, BMI GWAS (DOI: 10.1093/hmg/ddy271); Liu et al., 2019 Cigarettes per day (doi: 10.1038/s41588-018-0307-5); UKBB smoking status; UKBB liking of taking stairs; UKBB falls in last year; UKBB use of false teeth; UKBB Hypertension status; UKBB Vitamin E supplement use; UKBB Zinc supplement use.

The columns are:

SNP -rsid/Single Nucleotide Polymorphism identifier

CHR - chromsome

BP -Base position (Build 37)

A1 - Effect allele

A2 - Non -effect allele

Z - Z score

N - Sample Size

FRQ - Frequency

mtag_beta - effect estimate from MTAG of the effect allele

mtag_se - standard error of the effect estimate from MTAG

mtag_z - mtag_beta/mtag_se

mtag_pval - p value of the effect estimate