Development and Evaluation of In - Situ Nasal Gel of Candesartan Cilexetil

Now a day’s Nasal route is successfully used for the systemic delivery of various drugs like antidiabetic, antidepressants, vitamins and insulin delivery as it avoids first pass metabolism, gastrointestinal irritation, increases the bioavailability and residence time. The large surface area of the nasal mucosa offers a rapid onset of therapeutic effect, potential for direct-to-central nervous system delivery, no first-pass metabolism, and non- invasiveness; all of which may maximize patient convenience, comfort, and compliance. In the present investigation, an attempt was made to develop the pH sensitive nasal in-situ gel of Candesartan Cilexetil (2.5%) for controlling the drug release in the nasal tissues. Two polymers have been used i.e. Carbopol 940 and Xanthan gum. Carbopol 940 is the pH sensitive Mucoadhesive polymer. Xanthan gum has better effect on viscosity when exposed to the pH range 4.5-6.5. These conditions resemble the physiological conditions of the nose. The pH sensitive in-situ nasal gel so prepared were characterized for its clarity, pH, viscosity, gel strength, Mucoadhesive strength, drug content, in-vitro drug release and in-vitro permeation. This optimized formulation offers an alternative to conventional oral formulations and addresses food interaction issues.