Repository of the Silies lab
Published December 12, 2023 | Version v1
Dataset Open

Heterogeneity of synaptic connectivity in the fly visual system

Creators

  • 1. ROR icon Johannes Gutenberg University Mainz
  • 2. ROR icon Harvard Medical School

Description

Source data of the paper Cornean, Molina-Obando et al. 2024, Nature Communications. This work contains an analysis of synaptic connectivity in the Drosophila system, focusing on the presynaptic circuitry of three medulla interneurons, Tm9, Tm1, and Tm2.
Synaptic connectivity was analyzed using the FAFB dataset (Zheng et al. 2018 Cell) and the Flywire connectome (Schlegel et al. 2023 bioRxiv, Dorkenwald et al. 2023 bioRxiv), as well as expansion microscopy. This analysis is supplement by some functional analysis using in vivo 2-photon calcium imaging. 

Connectomics data used for this study are provided as .xlsx and .text files containing raw and processed data. 
Expansion microscopy are uploaded as .tiff files containing raw data, as well as .nrrd and .csv files containing processed data.
Calcium imaging data are provided at .mat files containing both raw and processed data, as well as .xml files with information about the experimental protocol.

Please find all relevant information to use the code in the README files.

The code to analyze the data, either written in Matlab or Python, is found at https://github.com/silieslab/Cornean_Molina-Obando_etal_2024.git

Files

data.zip

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Additional details

Related works

Is supplement to
Publication: 10.1101/2023.08.29.555204 (DOI)

Funding

European Commission
MicroCyFly – Microcircuitry of the Drosophila visual system 716512
Deutsche Forschungsgemeinschaft
From Imprecision to Robustness in Neural Circuit Assembly (P5) FOR5289
Deutsche Forschungsgemeinschaft
Eigene Stelle SCHN1479/1-1
Johannes Gutenberg University Mainz
FTN Stipend 2023
German National Academic Foundation
Stipend 2022