The overarching mission of this project is to develop a Center entitled PRE-Clinical Interagency reSearch resourcE-Traumatic Brain Injury (PRECISE-TBI) with the mission of accelerating the development of therapies for TBI. The strategic missions of the Center are divided into five Cores. The overarching goal of the Preclinical Model Catalogue Core is the creation, dissemination and maintenance of an online catalogue of preclinical models of TBI as well as create a database of preclinical TBI outcomes that are ontological to human TBI pathologies. The Common Data Elements Core mission is to develop and then benchmark new and existing common data elements using existing data from funded consortia and data from new endeavors. The Informatics Core seeks to fuel knowledge discovery through the development and implementation of a researcher-friendly infrastructure to support data sharing and implement standards and practices to make preclinical TBI data Findable, Accessible, Interoperable, and Reusable (FAIR). The mission of the Field TBI Program Coordination Core is to provide a bridge between the Center and the larger TBI community by leveraging existing infrastructure and growing the interactive community to use Center resources. Collectively, the Leadership, Steering Committee, Community Committee and Cores of PRECISE-TBI will support and accelerate the development of new candidate therapies for TBI.