Current Bioscience publishes articles that highlight the most significant advances in different fields of bioscience research. The spectrum of topics includes, but is not limited to, microbiology, immunology, pathology, and environmental factors that influence human and animal health.
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Current Issue of Current Bioscience
Current Bioscience. 2021; Vol. 1, No. 1.
Phage display identification of immunodominant epitopes and autoantibodies in autoimmune diseases
February 2021/in Article, Immunology /
Marco Palma
The phage display is a powerful technique to identify pathogenic binding sites implicated in autoimmune diseases (ADs). With chimeras of binding peptides can be identified amino acid residues implicated in the binding and defined more precisely the pathogenic epitope such as in the α3(IV)NC1 domain of Goodpasture disease. Epitope sharing….
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Bacterial molecular mimicry in autoimmune diseases
February 2021/in Article, Microbiology /
Marco Palma
Molecular mimicry is one of the main mechanisms by which bacteria induce autoimmunity. It occurs when bacterial components have sequential or structural similarity with self-peptides inducing the activation of autoreactive T or B cells. Several bacteria can induce an autoimmune response by molecular mimicry mechanism..